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Orc1 origin recognition complex, subunit 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313479, updated on 6-Jun-2024

Summary

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Official Symbol
Orc1provided by RGD
Official Full Name
origin recognition complex, subunit 1provided by RGD
Primary source
RGD:631435
See related
Ensembl:ENSRNOG00000008841 AllianceGenome:RGD:631435
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Orc1l
Summary
Enables chromatin binding activity. Involved in positive regulation of G0 to G1 transition and positive regulation of smooth muscle cell proliferation. Located in nucleus. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 1. Orthologous to human ORC1 (origin recognition complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 55.4), Spleen (RPKM 48.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Orc1 in Genome Data Viewer
Location:
5q34
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (128552975..128581943)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (123324273..123348375)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (128186651..128212901)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene terminal uridylyl transferase 4 Neighboring gene uncharacterized LOC134486964 Neighboring gene pre-mRNA processing factor 38A Neighboring gene coiled-coil and C2 domain containing 1B Neighboring gene zinc finger FYVE-type containing 9 Neighboring gene ribosomal protein L9, pseudogene 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RNA interference targeting ORC1 gene suppresses the proliferation of vascular smooth muscle cells in rats. Shu MQ, et al. Exp Mol Pathol, 2008 Jun. PMID 18499104
  2. Binding of AlF-C, an Orc1-binding transcriptional regulator, enhances replicator activity of the rat aldolase B origin. Minami H, et al. Mol Cell Biol, 2006 Dec. PMID 16982680, Free PMC Article
  3. Novel splicing variant of mouse Orc1 is deficient in nuclear translocation and resistant for proteasome-mediated degradation. Miyake Y, et al. J Biol Chem, 2005 Apr 1. PMID 15634681
  4. Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammals. Natale DA, et al. EMBO J, 2000 Jun 1. PMID 10835370, Free PMC Article
  5. ATP-dependent assembly of the human origin recognition complex. Siddiqui K, et al. J Biol Chem, 2007 Nov 2. PMID 17716973

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of G0 to G1 transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear origin of replication recognition complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear origin of replication recognition complex IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear origin of replication recognition complex ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear origin of replication recognition complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of origin recognition complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
origin recognition complex subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177931.2 → NP_808792.1  origin recognition complex subunit 1

    See identical proteins and their annotated locations for NP_808792.1

    Status: PROVISIONAL

    Source sequence(s)
    AB105378
    UniProtKB/Swiss-Prot
    Q80Z32
    UniProtKB/TrEMBL
    A0A8I6A918
    Conserved Domains (5) summary
    cd04719
    Location:43 → 169
    BAH_Orc1p_animal; BAH, or Bromo Adjacent Homology domain, as present in animal homologs of Saccharomyces cerevisiae Orc1p. Orc1 is part of the Yeast Sir1-origin recognition complex. The Orc1p BAH doman functions in epigenetic silencing. In vertebrates, a similar ORC ...
    TIGR02928
    Location:482 → 814
    TIGR02928; orc1/cdc6 family replication initiation protein
    pfam09079
    Location:765 → 838
    Cdc6_C; CDC6, C terminal
    pfam13191
    Location:491 → 541
    AAA_16; AAA ATPase domain
    cl21455
    Location:517 → 662
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    128552975..128581943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238515.5 → XP_006238577.1  origin recognition complex subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_006238577.1

    UniProtKB/TrEMBL
    A0A8I6A918, A6JYV4
    Related
    ENSRNOP00000012492.6
    Conserved Domains (5) summary
    cd04719
    Location:43 → 169
    BAH_Orc1p_animal; BAH, or Bromo Adjacent Homology domain, as present in animal homologs of Saccharomyces cerevisiae Orc1p. Orc1 is part of the Yeast Sir1-origin recognition complex. The Orc1p BAH doman functions in epigenetic silencing. In vertebrates, a similar ORC ...
    TIGR02928
    Location:482 → 814
    TIGR02928; orc1/cdc6 family replication initiation protein
    pfam09079
    Location:765 → 838
    Cdc6_C; CDC6, C terminal
    pfam13191
    Location:491 → 541
    AAA_16; AAA ATPase domain
    cl21455
    Location:517 → 662
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_063287715.1 → XP_063143785.1  origin recognition complex subunit 1 isoform X3

  3. XM_039109968.2 → XP_038965896.2  origin recognition complex subunit 1 isoform X2

    UniProtKB/TrEMBL
    G3V768
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80Z32.1 GenPept UniProtKB/Swiss-Prot:Q80Z32

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