Reck reversion-inducing-cysteine-rich protein with kazal motifs [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Reckprovided by RGD
Official Full Name: reversion-inducing-cysteine-rich protein with kazal motifsprovided by RGD
Primary source: RGD:1308845
See related: EnsemblRapid:ENSRNOG00000014863 AllianceGenome:RGD:1308845
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable Wnt-protein binding activity; coreceptor activity involved in canonical Wnt signaling pathway; and metalloendopeptidase inhibitor activity. Predicted to be involved in several processes, including blood vessel development; negative regulation of metalloendopeptidase activity; and positive regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within embryo implantation and embryonic forelimb morphogenesis. Predicted to be part of Wnt signalosome. Predicted to be active in plasma membrane. Orthologous to human RECK (reversion inducing cysteine rich protein with kazal motifs). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 136.9), Kidney (RPKM 61.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (62898717..62965274)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (58102961..58169516)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (59348568..59415169)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-200b-3p accelerates progression of pituitary adenomas by negatively regulating expression of RECK.
Title: miR-200b-3p accelerates progression of pituitary adenomas by negatively regulating expression of RECK.
Transient Expression of Reck Under Hepatic Ischemia/Reperfusion Conditions Is Associated with Mapk Signaling Pathways.
Title: Transient Expression of Reck Under Hepatic Ischemia/Reperfusion Conditions Is Associated with Mapk Signaling Pathways.
Increased Mmp/Reck Expression Ratio Is Associated with Increased Recognition Memory Performance in a Parkinson's Disease Animal Model.
Title: Increased Mmp/Reck Expression Ratio Is Associated with Increased Recognition Memory Performance in a Parkinson's Disease Animal Model.
Data suggest that reversion-inducing-cysteine-rich protein with kazal motifs (Reck) and SPARC Glycoprotein (Sparc) seem to play a role during ovarian dynamics: Reck as a possible inhibitor and Sparc as an inducer of matrix metalloproteinases (Mmps).
Title: Spatio-temporal expression profile of matrix metalloproteinase (Mmp) modulators Reck and Sparc during the rat ovarian dynamics.
Stromal cells upregulate RECK expression to regulate matrix metalloproteinase activity responsible for extracellular matrix changes occurring after castration.
Title: RECK expression in the rat ventral prostate: response to castration involves a balance between epithelial and stromal expression.
Differential expression of MMPs-2, -9 and RECK in the different phases of amelogenesis was found, suggesting that the tissue remodeling is rigorously controlled during dental mineralization.
Title: Rat forming incisor requires a rigorous ECM remodeling modulated by MMP/RECK balance.
TGF-beta signaling in activated PSCs may promote ECM accumulation via a mechanism that preserves the protease inhibitory activity of RECK
Title: TGF-beta signaling preserves RECK expression in activated pancreatic stellate cells.
Results show that RECK is differentially expressed by osteogenic and connective cells during several events of alveolar bone regeneration.
Title: Expression of matrix metalloproteinases-2 and -9 and RECK during alveolar bone regeneration in rat.

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General gene information

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Markers

RH130414 (e-PCR)
- UniSTS:213698

AU028681 (e-PCR)
- UniSTS:112091

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Wnt-protein binding	ISO Inferred from Sequence Orthology more info
enables coreceptor activity	ISO Inferred from Sequence Orthology more info
enables endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in blood vessel maturation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within blood vessel maturation	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryo implantation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic forelimb morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of establishment of blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in regulation of extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in sprouting angiogenesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Wnt signalosome	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: reversion-inducing cysteine-rich protein with Kazal motifs

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001415923.1 → NP_001402852.1 reversion-inducing cysteine-rich protein with Kazal motifs precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A0G2JZ40, A6IJ58

Related

ENSRNOP00000070900.1, ENSRNOT00000084031.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

62898717..62965274

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287725.1 → XP_063143795.1 reversion-inducing cysteine-rich protein with Kazal motifs isoform X1
XM_006238069.4 → XP_006238131.1 reversion-inducing cysteine-rich protein with Kazal motifs isoform X2

UniProtKB/TrEMBL

A0A8I5ZRL0

Conserved Domains (1) summary

pfam14828
Location:674 → 739

Amnionless; Amnionless

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001107954.1: Suppressed sequence

Description

NM_001107954.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.