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Pafah2 platelet-activating factor acetylhydrolase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313611, updated on 2-Nov-2024

Summary

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Official Symbol
Pafah2provided by RGD
Official Full Name
platelet-activating factor acetylhydrolase 2provided by RGD
Primary source
RGD:631399
See related
EnsemblRapid:ENSRNOG00000022288 AllianceGenome:RGD:631399
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables 1-alkyl-2-acetylglycerophosphocholine esterase activity and platelet-activating factor acetyltransferase activity. Involved in negative regulation of apoptotic process. Predicted to be located in cytoplasm. Orthologous to human PAFAH2 (platelet activating factor acetylhydrolase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 175.0), Lung (RPKM 171.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pafah2 in Genome Data Viewer
Location:
5q36
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (151890751..151919896)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (146607050..146636203)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (152606850..152635956)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 30 member 2 Neighboring gene uncharacterized LOC120103006 Neighboring gene exostosin-like glycosyltransferase 1 Neighboring gene uncharacterized LOC102546373 Neighboring gene uncharacterized LOC134487004 Neighboring gene stathmin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Purification and characterization from rat kidney membranes of a novel platelet-activating factor (PAF)-dependent transacetylase that catalyzes the hydrolysis of PAF, formation of PAF analogs, and C2-ceramide. Karasawa K, et al. J Biol Chem, 1999 Mar 26. PMID 10085103
  2. Anti-apoptotic actions of the platelet-activating factor acetylhydrolase I alpha2 catalytic subunit. Bonin F, et al. J Biol Chem, 2004 Dec 10. PMID 15456758
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IEA
Inferred from Electronic Annotation
more info
  
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables platelet-activating factor acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
platelet-activating factor acetylhydrolase 2, cytoplasmic
Names
PAF:lysophospholipid transacetylase
PAF:sphingosine transacetylase
SD-PLA2
platelet-activating factor acetylhydrolase 2, 40kDa
platelet-activating factor acetyltransferase PAFAH2
serine-dependent phospholipase A2
NP_808793.1
XP_006239189.1
XP_017448893.1
XP_038965969.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177932.2 → NP_808793.1  platelet-activating factor acetylhydrolase 2, cytoplasmic

    See identical proteins and their annotated locations for NP_808793.1

    Status: PROVISIONAL

    Source sequence(s)
    AY225592
    UniProtKB/Swiss-Prot
    P83006, Q80Z89
    UniProtKB/TrEMBL
    A6IT19, A6IT20
    Related
    ENSRNOP00000103411.1, ENSRNOT00000166584.1
    Conserved Domains (1) summary
    pfam03403
    Location:1 → 379
    PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    151890751..151919896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017593404.3 → XP_017448893.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform X1

    UniProtKB/Swiss-Prot
    P83006, Q80Z89
    UniProtKB/TrEMBL
    A6IT19, A6IT20
    Conserved Domains (1) summary
    pfam03403
    Location:1 → 379
    PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

  2. XM_039110041.2 → XP_038965969.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform X1

    UniProtKB/Swiss-Prot
    P83006, Q80Z89
    UniProtKB/TrEMBL
    A6IT19, A6IT20
    Conserved Domains (1) summary
    pfam03403
    Location:1 → 379
    PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

  3. XM_006239127.5 → XP_006239189.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform X1

    See identical proteins and their annotated locations for XP_006239189.1

    UniProtKB/Swiss-Prot
    P83006, Q80Z89
    UniProtKB/TrEMBL
    A6IT19, A6IT20
    Conserved Domains (1) summary
    pfam03403
    Location:1 → 379
    PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

RNA

  1. XR_001837842.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P83006.2 GenPept UniProtKB/Swiss-Prot:P83006

Gene LinkOut

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