Maco1 macoilin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Maco1provided by RGD
Official Full Name: macoilin 1provided by RGD
Primary source: RGD:1561685
See related: EnsemblRapid:ENSRNOG00000056156 AllianceGenome:RGD:1561685
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tmem57
Summary: Predicted to enable microtubule binding activity. Predicted to be involved in chemotaxis and neuronal signal transduction. Predicted to act upstream of or within brain development. Predicted to be located in several cellular components, including axon; neuron projection terminus; and synapse. Predicted to be active in nuclear membrane and rough endoplasmic reticulum membrane. Orthologous to human MACO1 (macoilin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 118.1), Adrenal (RPKM 111.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (152296107..152358684, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (147012416..147075265, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (153122780..153184940, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

UniSTS:235065 (e-PCR)
- UniSTS:235065

BF403341 (e-PCR)
- UniSTS:246414

D6S1937 (e-PCR)
- UniSTS:41673

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuronal signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuronal signal transduction	ISO Inferred from Sequence Orthology more info
involved_in neuronal signal transduction	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuron projection terminus	ISO Inferred from Sequence Orthology more info
is_active_in nuclear membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in rough endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in rough endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in rough endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: macoilin

Names: transmembrane protein 57

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025699.2 → NP_001020870.2 macoilin

See identical proteins and their annotated locations for NP_001020870.2

Status: PROVISIONAL

Source sequence(s)

AY845021

UniProtKB/Swiss-Prot

Q2TLZ0, Q4V7D3

Related

ENSRNOP00000069310.1, ENSRNOT00000079536.3

Conserved Domains (3) summary

TIGR03462
Location:29 → 113

CarR_dom_SF; lycopene cyclase domain

pfam09726
Location:2 → 662

Macoilin; Transmembrane protein

pfam16331
Location:386 → 462

TolA_bind_tri; TolA binding protein trimerization