U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Plekhm2 pleckstrin homology and RUN domain containing M2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313667, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Plekhm2provided by RGD
Official Full Name
pleckstrin homology and RUN domain containing M2provided by RGD
Primary source
RGD:1307005
See related
EnsemblRapid:ENSRNOG00000012163 AllianceGenome:RGD:1307005
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable kinesin binding activity. Predicted to be involved in several processes, including Golgi organization; lysosome localization; and natural killer cell mediated cytotoxicity. Predicted to be located in lysosomal membrane. Predicted to be active in endosome membrane. Orthologous to human PLEKHM2 (pleckstrin homology and RUN domain containing M2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 112.9), Brain (RPKM 91.7) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Plekhm2 in Genome Data Viewer
Location:
5q36
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (159222620..159261666, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (153939582..153978625, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (160182556..160219770, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134487029 Neighboring gene solute carrier family 25, member 34 Neighboring gene transmembrane protein 82 Neighboring gene DNA damage inducible 1 homolog 2 Neighboring gene agmatinase Neighboring gene DnaJ heat shock protein family (Hsp40) member C16

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The intracellular fate of Salmonella depends on the recruitment of kinesin. Boucrot E, et al. Science, 2005 May 20. PMID 15905402
  2. Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulation. Ohlson MB, et al. Cell Host Microbe, 2008 Nov 13. PMID 18996344, Free PMC Article
  3. The Salmonella virulence protein SifA is a G protein antagonist. Jackson LK, et al. Proc Natl Acad Sci U S A, 2008 Sep 16. PMID 18787122, Free PMC Article
  4. BORC, a multisubunit complex that regulates lysosome positioning. Pu J, et al. Dev Cell, 2015 Apr 20. PMID 25898167, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables kinesin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in lysosome localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lysosome localization ISO
Inferred from Sequence Orthology
more info
  
involved_in natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
pleckstrin homology domain-containing family M member 2
Names
pleckstrin homology domain containing, family M (with RUN domain) member 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191767.1 → NP_001178696.1  pleckstrin homology domain-containing family M member 2

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I6GI53, D4A932
    Related
    ENSRNOP00000016333.5, ENSRNOT00000016333.9
    Conserved Domains (3) summary
    smart00593
    Location:93 → 156
    RUN; domain involved in Ras-like GTPase signaling
    cd13309
    Location:785 → 887
    PH_SKIP; SifA and kinesin-interacting protein Pleckstrin homology (PH) domain
    pfam00169
    Location:784 → 885
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    159222620..159261666 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110081.2 → XP_038966009.1  pleckstrin homology domain-containing family M member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A4P1, A0A8I6GI53
    Related
    ENSRNOP00000087716.1, ENSRNOT00000096039.2
    Conserved Domains (3) summary
    smart00593
    Location:93 → 156
    RUN; domain involved in Ras-like GTPase signaling
    PHA03247
    Location:389 → 552
    PHA03247; large tegument protein UL36; Provisional
    cd13309
    Location:765 → 867
    PH_SKIP; SifA and kinesin-interacting protein Pleckstrin homology (PH) domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools