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Ddi2 DNA damage inducible 1 homolog 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313668, updated on 17-Aug-2024

Summary

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Official Symbol
Ddi2provided by RGD
Official Full Name
DNA damage inducible 1 homolog 2provided by RGD
Primary source
RGD:1311815
See related
EnsemblRapid:ENSRNOG00000012274 AllianceGenome:RGD:1311815
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311815
Summary
Predicted to enable aspartic-type endopeptidase activity; identical protein binding activity; and ubiquitin binding activity. Predicted to be involved in several processes, including cellular response to hydroxyurea; proteolysis; and regulation of DNA stability. Predicted to be located in cytosol and nucleoplasm. Orthologous to several human genes including DDI2 (DNA damage inducible 1 homolog 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 307.6), Kidney (RPKM 214.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ddi2 in Genome Data Viewer
Location:
5q36
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (159272625..159318365, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (153989591..154035342, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (160230958..160282836, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 25, member 34 Neighboring gene pleckstrin homology and RUN domain containing M2 Neighboring gene agmatinase Neighboring gene DnaJ heat shock protein family (Hsp40) member C16 Neighboring gene caspase 9 Neighboring gene chymotrypsin like elastase 2A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human DNA-Damage-Inducible 2 Protein Is Structurally and Functionally Distinct from Its Yeast Ortholog. Sivá M, et al. Sci Rep, 2016 Jul 27. PMID 27461074, Free PMC Article
  2. Reply to Vangala et al.: Complete inhibition of the proteasome reduces new proteasome production by causing Nrf1 aggregation. Sha Z, et al. Curr Biol, 2016 Sep 26. PMID 27676298, Free PMC Article
  3. The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction. Koizumi S, et al. Elife, 2016 Aug 16. PMID 27528193, Free PMC Article
  4. Removal of RTF2 from Stalled Replisomes Promotes Maintenance of Genome Integrity. Kottemann MC, et al. Mol Cell, 2018 Jan 4. PMID 29290612, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to hydroxyurea ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA stability ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein DDI1 homolog 2
Names
DNA-damage inducible protein 2
NP_001382515.1
XP_006239367.1
XP_006239368.1
XP_006239370.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395586.1 → NP_001382515.1  protein DDI1 homolog 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8J8Y1M0
    Conserved Domains (2) summary
    cd05479
    Location:221 → 343
    RP_DDI; retropepsin-like domain of DNA damage inducible protein
    cd01796
    Location:1 → 76
    Ubl_Ddi1_like; ubiquitin-like (Ubl) domain found in the eukaryotic Ddi1 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    159272625..159318365 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239305.5 → XP_006239367.1  protein DDI1 homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y0Y2, A0A8I6GFW9
    Related
    ENSRNOP00000077256.1, ENSRNOT00000119479.2
    Conserved Domains (4) summary
    cd05479
    Location:221 → 343
    RP_DDI; RP_DDI; retropepsin-like domain of DNA damage inducible protein
    cd01796
    Location:3 → 76
    DDI1_N; DNA damage inducible protein 1 ubiquitin-like domain
    smart00213
    Location:1 → 74
    UBQ; Ubiquitin homologues
    pfam09786
    Location:387 → 535
    CytochromB561_N; Cytochrome B561, N terminal

  2. XM_006239306.5 → XP_006239368.1  protein DDI1 homolog 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GFW9
    Related
    ENSRNOP00000087348.1, ENSRNOT00000109253.2
    Conserved Domains (3) summary
    cd05479
    Location:218 → 340
    RP_DDI; RP_DDI; retropepsin-like domain of DNA damage inducible protein
    pfam09786
    Location:384 → 532
    CytochromB561_N; Cytochrome B561, N terminal
    cl00155
    Location:43 → 73
    UBQ; Ubiquitin-like proteins

  3. XM_006239308.5 → XP_006239370.1  protein DDI1 homolog 2 isoform X3

    UniProtKB/TrEMBL
    A6ITV4
    Related
    ENSRNOP00000016352.8, ENSRNOT00000016352.8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001034149.1: Suppressed sequence

    Description
    NM_001034149.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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