Ubiad1 UbiA prenyltransferase domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ubiad1provided by RGD
Official Full Name: UbiA prenyltransferase domain containing 1provided by RGD
Primary source: RGD:1309588
See related: EnsemblRapid:ENSRNOG00000009575 AllianceGenome:RGD:1309588
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309588
Summary: Predicted to enable antioxidant activity and prenyltransferase activity. Predicted to be involved in several processes, including menaquinone biosynthetic process; ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate; and vitamin K biosynthetic process. Predicted to be located in cytoplasm; membrane; and nucleus. Predicted to be active in Golgi membrane and endoplasmic reticulum. Human ortholog(s) of this gene implicated in Schnyder corneal dystrophy. Orthologous to human UBIAD1 (UbiA prenyltransferase domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 52.9), Heart (RPKM 50.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (164139714..164167777, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (158856582..158880490, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (165247630..165259228, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Low Ubiad1 expression is associated with cardiac hypertrophy in spontaneously hypertensive rats.
Title: UBIAD1 expression is associated with cardiac hypertrophy in spontaneously hypertensive rats.
In a rat model of chronic kidney disease, there was a decrease in the thoracic aorta expression of Vkor and Ggcx enzymes, and a decrease in the kidney level of vitamin K1 to MK-4 bioconversion enzyme Ubiad1.
Title: Vitamin K Metabolism in a Rat Model of Chronic Kidney Disease.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables antioxidant activity	ISO Inferred from Sequence Orthology more info
enables antioxidant activity	ISS Inferred from Sequence or Structural Similarity more info
enables prenyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables prenyltransferase activity	ISO Inferred from Sequence Orthology more info
enables prenyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in circulatory system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in endothelial cell development	ISS Inferred from Sequence or Structural Similarity more info
involved_in menaquinone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in menaquinone biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in menaquinone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in menaquinone biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in ubiquinone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquinone biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate	IBA Inferred from Biological aspect of Ancestor more info
involved_in vitamin K biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in vitamin K biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in vitamin K biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiA prenyltransferase domain-containing protein 1

NP_001101463.1

EC 2.5.1.39

XP_038966026.1

EC 2.5.1.39

XP_038966027.1

EC 2.5.1.39

XP_063143903.1

EC 2.5.1.39

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107993.1 → NP_001101463.1 ubiA prenyltransferase domain-containing protein 1

See identical proteins and their annotated locations for NP_001101463.1

Status: PROVISIONAL

Source sequence(s)

CH473968

UniProtKB/Swiss-Prot

D3ZG27

Related

ENSRNOP00000012691.3, ENSRNOT00000012692.7

Conserved Domains (1) summary

cd13962
Location:50 → 326

PT_UbiA_UBIAD1; 1,4-Dihydroxy-2-naphthoate octaprenyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

164139714..164167777 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039110099.2 → XP_038966027.1 ubiA prenyltransferase domain-containing protein 1 isoform X2

Conserved Domains (1) summary

cd13962
Location:50 → 176

PT_UbiA_UBIAD1; 1,4-Dihydroxy-2-naphthoate octaprenyltransferase
XM_063287833.1 → XP_063143903.1 ubiA prenyltransferase domain-containing protein 1 isoform X3
XM_039110098.2 → XP_038966026.1 ubiA prenyltransferase domain-containing protein 1 isoform X1

Conserved Domains (1) summary

cd13962
Location:50 → 180

PT_UbiA_UBIAD1; 1,4-Dihydroxy-2-naphthoate octaprenyltransferase