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norpA no receptor potential A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31376, updated on 2-Nov-2024

Summary

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Official Symbol
norpAprovided by FlyBase
Official Full Name
no receptor potential Aprovided by FlyBase
Primary source
FLYBASE:FBgn0262738
Locus tag
Dmel_CG3620
See related
AllianceGenome:FB:FBgn0262738
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Posey221; CdkA; CG3620; DIP2; Dmel\CG3620; MRE18; nofC; NorpA; NORPA; PI-PLC; PLC; PLC-beta; PLCbeta; rof; x12; x13; x16; x24
Summary
Enables GTPase activator activity and phosphatidylinositol phospholipase C activity. Involved in several processes, including detection of chemical stimulus involved in sensory perception of bitter taste; entrainment of circadian clock by photoperiod; and negative regulation of compound eye retinal cell programmed cell death. Located in rhabdomere. Part of inaD signaling complex. Is expressed in several structures, including Bolwig nerve; brain; organism subdivision; photoreceptor; and photoreceptor neurons. Used to study retinal degeneration and retinal disease. Orthologous to human PLCB4 (phospholipase C beta 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See norpA in Genome Data Viewer
Location:
4B6-4C1; 1-8 cM
Exon count:
19
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4322626..4365408)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4216659..4259441)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Nucleolar protein 66 Neighboring gene mitochondrial ribosomal protein L33 Neighboring gene uncharacterized protein Neighboring gene mir-982 stem loop Neighboring gene mir-303 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Membrane association of phospholipase C encoded by the norpA gene of Drosophila melanogaster. McKay RR, et al. Neuroscience, 1994 Jul. PMID 7969889
  2. Phototransduction mutants of Drosophila melanogaster. Alawi AA, et al. Adv Exp Med Biol, 1972. PMID 4137105
  3. Protein differences associated with a phototransduction mutant of Drosophila. Ostroy SE, et al. Nat New Biol, 1973 May 23. PMID 4196640
  4. Reversibly temperature sensitive phototransduction mutant of Drosophila melanogaster. Deland MC, et al. Nat New Biol, 1973 Aug 8. PMID 4198996
  5. Drosophila rhodopsin: photochemistry, extraction and differences in the norp AP12 phototransduction mutant. Ostroy SE, et al. Biochem Biophys Res Commun, 1974 Aug 5. PMID 4213042

See all (585) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Guided by the structure of the INAD-NORPA complex, we discover that INADL is probably a mammalian counterpart of INAD. The INADL PDZ89 tandem specifically binds to PLCb4 with a mode that is strikingly similar to that of the INAD-NORPA complex, as revealed by the structure of the INADL PDZ89-PLCb4 CC-PBM complex.
    Title: An unexpected INAD PDZ tandem-mediated plcβ binding in Drosophila photo receptors.
  2. This study demonstrated that NorpA and eya2 mutants with disrupted vision showed normal mating effects on sleep.
    Title: Mechanisms of sleep plasticity due to sexual experience in Drosophila melanogaster.
  3. These results provide evidence for the existence of a unique dPIP5K dependent pool of PIP2 required for normal Drosophila phototransduction.
    Title: A dPIP5K dependent pool of phosphatidylinositol 4,5 bisphosphate (PIP2) is required for G-protein coupled signal transduction in Drosophila photoreceptors.
  4. The positive feedback between PLCbeta and IP3R found here may represent a common feature of the inositol-lipid signaling
    Title: Functional cooperation between the IP3 receptor and phospholipase C secures the high sensitivity to light of Drosophila photoreceptors in vivo.
  5. Taken together, these findings reveal that PLC function in Drosophila sweet-sensing neurons is a conserved molecular signaling pathway that confers attraction to fatty acids
    Title: Drosophila fatty acid taste signals through the PLC pathway in sugar-sensing neurons.
  6. This review prestnted the evidence the norpA mutation have significantly contributed to understanding the molecular and biochemical basis of phototransduction in Drosophila.
    Title: Impact of studies of the Drosophila norpA mutation on understanding phototransduction.
  7. Light reception mediated by Rh5 and Rh6 must utilize either a different (nonretinal) phospholipase C-beta enzyme or alternative signaling mechanisms, at least in terms of clock-relevant photoreception
    Title: Rhodopsin 5- and Rhodopsin 6-mediated clock synchronization in Drosophila melanogaster is independent of retinal phospholipase C-β signaling.
  8. the Galphaq-PLCbeta-Ca(2+)-DUOX-ROS signaling pathway acts as a bona fide first line of defense that enables gut epithelia to dynamically control yeast during the Drosophila life cycle
    Title: Regulation of DUOX by the Galphaq-phospholipase Cbeta-Ca2+ pathway in Drosophila gut immunity.
  9. Analysis of norpA inaE double mutants and severe inaE mutants defective in photoreceptor respponses to light shows that normal diacylglycerol lipase activity is required for the generation of physiologically meaningful photoreceptor responses.
    Title: DAG lipase activity is necessary for TRP channel regulation in Drosophila photoreceptors.
  10. loss of the norpa gene product induces massive endocytosis of rhodopsin and arrestin in photoreceptors
    Title: Loss of the phospholipase C gene product induces massive endocytosis of rhodopsin and arrestin in Drosophila photoreceptors.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phospholipase C activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity TAS
Traceable Author Statement
more info
 PubMed 
enables phospholipase C activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in calcium-mediated signaling TAS
Traceable Author Statement
more info
 PubMed 
involved_in cellular response to light stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in circadian rhythm IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in detection of chemical stimulus involved in sensory perception of bitter taste IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in diacylglycerol biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in entrainment of circadian clock IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in entrainment of circadian clock by photoperiod IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mucosal immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of compound eye retinal cell programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in phospholipase C-activating opsin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipase C-activating opsin-mediated signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in phospholipid biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in phospholipid metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in photoreceptor cell maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phototransduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of clathrin-dependent endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thermotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of inaD signaling complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of inaD signaling complex TAS
Traceable Author Statement
more info
 PubMed 
located_in rhabdomere IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
no receptor potential A
Names
CG3620-PA
CG3620-PB
CG3620-PC
CG3620-PD
CG3620-PE
CG3620-PF
No receptor potential A
eye-specific PLC
mRNA-like ncRNA in embryogenesis 18
no receptor potential
no receptor potentials A
no-receptor potential A
no-receptor-potential A
no-receptor-potential-A
norp A
norpA-PA
norpA-PB
norpA-PC
norpA-PD
norpA-PE
norpA-PF
phospholipase C
phospholipase C-beta
phospholipase C[[beta]]
phospholipase cbeta
phospholipase-C
NP_001014720.1
NP_001014721.1
NP_001162661.1
NP_001284860.1
NP_525069.2
NP_726925.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    4322626..4365408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169190.2 → NP_001162661.1  no receptor potential A, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162661.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V3Y2, P13217, Q59E70, Q86P93, Q9U4G4, Q9W4K9
    UniProtKB/TrEMBL
    E1JJD5
    Conserved Domains (7) summary
    cd00275
    Location:689 → 806
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:318 → 653
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:224 → 786
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:17 → 149
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:866 → 908
    DUF1154; Protein of unknown function (DUF1154)
    pfam09074
    Location:887 → 1003
    Mer2; Mer2
    pfam09279
    Location:227 → 318
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

  2. NM_001014720.2 → NP_001014720.1  no receptor potential A, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014720.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JCI4
    Conserved Domains (7) summary
    cd00275
    Location:689 → 806
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:318 → 653
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:224 → 786
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:17 → 149
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:866 → 908
    DUF1154; Protein of unknown function (DUF1154)
    pfam09074
    Location:887 → 1003
    Mer2; Mer2
    pfam09279
    Location:227 → 318
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

  3. NM_167008.2 → NP_726925.1  no receptor potential A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726925.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V3Y2, P13217, Q59E70, Q86P93, Q9U4G4, Q9W4K9
    UniProtKB/TrEMBL
    E1JJD5
    Related
    FBpp0070618
    Conserved Domains (7) summary
    cd00275
    Location:689 → 806
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:318 → 653
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:224 → 786
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:17 → 149
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:866 → 908
    DUF1154; Protein of unknown function (DUF1154)
    pfam09074
    Location:887 → 1003
    Mer2; Mer2
    pfam09279
    Location:227 → 318
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

  4. NM_001297931.1 → NP_001284860.1  no receptor potential A, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284860.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JCI4
    Conserved Domains (7) summary
    cd00275
    Location:689 → 806
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:318 → 653
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:224 → 786
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:17 → 149
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:866 → 908
    DUF1154; Protein of unknown function (DUF1154)
    pfam09074
    Location:887 → 1003
    Mer2; Mer2
    pfam09279
    Location:227 → 318
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

  5. NM_080330.4 → NP_525069.2  no receptor potential A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525069.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V3Y2, P13217, Q59E70, Q86P93, Q9U4G4, Q9W4K9
    UniProtKB/TrEMBL
    E1JJD5
    Related
    FBpp0070619
    Conserved Domains (7) summary
    cd00275
    Location:689 → 806
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:318 → 653
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:224 → 786
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:17 → 149
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:866 → 908
    DUF1154; Protein of unknown function (DUF1154)
    pfam09074
    Location:887 → 1003
    Mer2; Mer2
    pfam09279
    Location:227 → 318
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

  6. NM_001014721.3 → NP_001014721.1  no receptor potential A, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014721.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JCI4
    Conserved Domains (7) summary
    cd00275
    Location:689 → 806
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:318 → 653
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:224 → 786
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:17 → 149
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:866 → 908
    DUF1154; Protein of unknown function (DUF1154)
    pfam09074
    Location:887 → 1003
    Mer2; Mer2
    pfam09279
    Location:227 → 318
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JJD5 E1JJD5
P13217.4 P13217
X2JCI4 X2JCI4

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