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Acap3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313772, updated on 10-Jul-2024

Summary

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Official Symbol
Acap3provided by RGD
Official Full Name
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3provided by RGD
Primary source
RGD:1310711
See related
EnsemblRapid:ENSRNOG00000022307 AllianceGenome:RGD:1310711
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Centb5
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in regulation of catalytic activity. Predicted to act upstream of or within neuron migration and regulation of neuron projection development. Predicted to be located in growth cone. Orthologous to human ACAP3 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 101.3), Lung (RPKM 65.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Acap3 in Genome Data Viewer
Location:
5q36
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171783382..171797709)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166501150..166515477)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (173340060..173354756)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ceramide-1-phosphate transfer protein Neighboring gene integrator complex subunit 11 Neighboring gene pseudouridine synthase like 1 Neighboring gene sodium channel epithelial 1 delta subunit Neighboring gene ubiquitin-conjugating enzyme E2, J2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ACAP3, the GTPase-activating protein specific to the small GTPase Arf6, regulates neuronal migration in the developing cerebral cortex. Miura Y, et al. Biochem Biophys Res Commun, 2017 Nov 18. PMID 28919417
  2. ACAP3 regulates neurite outgrowth through its GAP activity specific to Arf6 in mouse hippocampal neurons. Miura Y, et al. Biochem J, 2016 Sep 1. PMID 27330119

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within neuron migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in growth cone ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3
Names
centaurin, beta 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395748.1 → NP_001382677.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I6A5L6, A0A8I6GJX2
    Related
    ENSRNOP00000086578.1, ENSRNOT00000114207.2
    Conserved Domains (5) summary
    PTZ00322
    Location:705 → 800
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd07637
    Location:16 → 215
    BAR_ACAP3; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 3
    cd13250
    Location:271 → 367
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    sd00045
    Location:700 → 731
    ANK; ANK repeat [structural motif]
    cd08850
    Location:403 → 518
    ArfGap_ACAP3; ArfGAP domain of ACAP3 (ArfGAP with Coiled-coil, ANK repeat and PH domains 3)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    171783382..171797709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287838.1 → XP_063143908.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K5N8, A0A8I6A5L6
    Related
    ENSRNOP00000073498.2, ENSRNOT00000078306.3

  2. XM_063287839.1 → XP_063143909.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A5L6
    Related
    ENSRNOP00000061938.2, ENSRNOT00000067841.4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107999.1: Suppressed sequence

    Description
    NM_001107999.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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