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Galm galactose mutarotase [ Rattus norvegicus (Norway rat) ]

Gene ID: 313843, updated on 2-Nov-2024

Summary

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Official Symbol
Galmprovided by RGD
Official Full Name
galactose mutarotaseprovided by RGD
Primary source
RGD:1359459
See related
EnsemblRapid:ENSRNOG00000007023 AllianceGenome:RGD:1359459
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable aldose 1-epimerase activity. Predicted to be involved in galactose catabolic process via UDP-galactose and glucose metabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in galactosemia 4. Orthologous to human GALM (galactose mutarotase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 703.9), Liver (RPKM 280.8) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Galm in Genome Data Viewer
Location:
6q12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (20589775..20641516, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (14837540..14889484, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (2808988..2860742)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 39D Neighboring gene serine and arginine rich splicing factor 7 Neighboring gene uncharacterized LOC134479103 Neighboring gene uncharacterized LOC134479102 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and characterisation of human aldose 1-epimerase. Timson DJ, et al. FEBS Lett, 2003 May 22. PMID 12753898
  2. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC93738

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aldose 1-epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldose 1-epimerase activity IEA
Inferred from Electronic Annotation
more info
  
enables aldose 1-epimerase activity ISO
Inferred from Sequence Orthology
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in galactose catabolic process via UDP-galactose IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in galactose catabolic process via UDP-galactose IEA
Inferred from Electronic Annotation
more info
  
involved_in galactose catabolic process via UDP-galactose ISO
Inferred from Sequence Orthology
more info
  
involved_in galactose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
galactose mutarotase
Names
aldose 1-epimerase
NP_001007705.1
XP_063117896.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007704.1 → NP_001007705.1  galactose mutarotase

    See identical proteins and their annotated locations for NP_001007705.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081876
    UniProtKB/Swiss-Prot
    Q66HG4
    UniProtKB/TrEMBL
    A0A8L2Q447, A6H9S6
    Related
    ENSRNOP00000009221.6, ENSRNOT00000009221.8
    Conserved Domains (1) summary
    cd09019
    Location:21 → 339
    galactose_mutarotase_like; galactose mutarotase_like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    20589775..20641516 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261826.1 → XP_063117896.1  galactose mutarotase isoform X1

    Related
    ENSRNOP00000098662.1, ENSRNOT00000134334.1

RNA

  1. XR_005505503.2 RNA Sequence

  2. XR_005505502.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66HG4.1 GenPept UniProtKB/Swiss-Prot:Q66HG4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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