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Plekhh2 pleckstrin homology, MyTH4 and FERM domain containing H2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313866, updated on 2-Nov-2024

Summary

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Official Symbol
Plekhh2provided by RGD
Official Full Name
pleckstrin homology, MyTH4 and FERM domain containing H2provided by RGD
Primary source
RGD:1304935
See related
EnsemblRapid:ENSRNOG00000005124 AllianceGenome:RGD:1304935
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1304935
Summary
Predicted to enable actin binding activity. Predicted to be involved in negative regulation of actin filament depolymerization. Predicted to be located in several cellular components, including cortical actin cytoskeleton; lamellipodium; and nuclear body. Predicted to be active in cytoplasm. Orthologous to human PLEKHH2 (pleckstrin homology, MyTH4 and FERM domain containing H2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 97.0), Uterus (RPKM 70.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Plekhh2 in Genome Data Viewer
Location:
6q12
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (15783179..15893479, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (10032837..10132081, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (7784743..7895986)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene dynein cytoplasmic 2 light intermediate chain 1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134479315 Neighboring gene uncharacterized LOC134479314 Neighboring gene THADA, armadillo repeat containing Neighboring gene zinc finger protein 36, C3H type-like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Plekhh2, a novel podocyte protein downregulated in human focal segmental glomerulosclerosis, is involved in matrix adhesion and actin dynamics. Perisic L, et al. Kidney Int, 2012 Nov. PMID 22832517
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of actin filament depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of actin filament depolymerization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pleckstrin homology domain-containing family H member 2
Names
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191770.3 → NP_001178699.3  pleckstrin homology domain-containing family H member 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    15783179..15893479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261831.1 → XP_063117901.1  pleckstrin homology domain-containing family H member 2 isoform X1

    Related
    ENSRNOP00000006832.6, ENSRNOT00000006832.6

  2. XM_063261832.1 → XP_063117902.1  pleckstrin homology domain-containing family H member 2 isoform X2

  3. XM_063261838.1 → XP_063117908.1  pleckstrin homology domain-containing family H member 2 isoform X7

  4. XM_063261835.1 → XP_063117905.1  pleckstrin homology domain-containing family H member 2 isoform X5

  5. XM_063261830.1 → XP_063117900.1  pleckstrin homology domain-containing family H member 2 isoform X1

  6. XM_063261840.1 → XP_063117910.1  pleckstrin homology domain-containing family H member 2 isoform X9

  7. XM_063261841.1 → XP_063117911.1  pleckstrin homology domain-containing family H member 2 isoform X10

  8. XM_063261846.1 → XP_063117916.1  pleckstrin homology domain-containing family H member 2 isoform X13

  9. XM_063261839.1 → XP_063117909.1  pleckstrin homology domain-containing family H member 2 isoform X8

  10. XM_063261836.1 → XP_063117906.1  pleckstrin homology domain-containing family H member 2 isoform X6

  11. XM_063261843.1 → XP_063117913.1  pleckstrin homology domain-containing family H member 2 isoform X12

  12. XM_063261844.1 → XP_063117914.1  pleckstrin homology domain-containing family H member 2 isoform X12

  13. XM_063261837.1 → XP_063117907.1  pleckstrin homology domain-containing family H member 2 isoform X6

  14. XM_063261833.1 → XP_063117903.1  pleckstrin homology domain-containing family H member 2 isoform X3

  15. XM_063261834.1 → XP_063117904.1  pleckstrin homology domain-containing family H member 2 isoform X4

  16. XM_063261847.1 → XP_063117917.1  pleckstrin homology domain-containing family H member 2 isoform X14

  17. XM_063261849.1 → XP_063117919.1  pleckstrin homology domain-containing family H member 2 isoform X16

  18. XM_063261848.1 → XP_063117918.1  pleckstrin homology domain-containing family H member 2 isoform X15

  19. XM_063261842.1 → XP_063117912.1  pleckstrin homology domain-containing family H member 2 isoform X11

RNA

  1. XR_010052082.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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