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Gtf3c2 general transcription factor IIIC subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313914, updated on 2-Nov-2024

Summary

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Official Symbol
Gtf3c2provided by RGD
Official Full Name
general transcription factor IIIC subunit 2provided by RGD
Primary source
RGD:1560392
See related
EnsemblRapid:ENSRNOG00000056904 AllianceGenome:RGD:1560392
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
TFIIIC110
Summary
Predicted to enable RNA polymerase III general transcription initiation factor activity. Predicted to contribute to DNA binding activity. Predicted to be involved in transcription by RNA polymerase III. Predicted to be located in nucleoplasm. Predicted to be part of transcription factor TFIIIC complex. Orthologous to human GTF3C2 (general transcription factor IIIC subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 223.7), Kidney (RPKM 177.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gtf3c2 in Genome Data Viewer
Location:
6q14
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (30913263..30941305)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (25196439..25221338)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (26560601..26584533)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene sorting nexin 17 Neighboring gene eukaryotic translation initiation factor 2B subunit delta Neighboring gene mitochondrial inner membrane protein MPV17 Neighboring gene urocortin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. Dumay-Odelot H, et al. J Biol Chem, 2007 Jun 8. PMID 17409385
  2. A structural perspective on RNA polymerase I and RNA polymerase III transcription machineries. Vannini A. Biochim Biophys Acta, 2013 Mar-Apr. PMID 23031840
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase III general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in transcription by RNA polymerase III IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription by RNA polymerase III ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIIC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIIC complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
general transcription factor 3C polypeptide 2
Names
general transcription factor IIIC, polypeptide 2, beta 110kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025120.1 → NP_001020291.1  general transcription factor 3C polypeptide 2

    See identical proteins and their annotated locations for NP_001020291.1

    Status: PROVISIONAL

    Source sequence(s)
    BC087088
    UniProtKB/TrEMBL
    A0A0G2JY75, A0A8I6A405, Q5PQP7
    Related
    ENSRNOP00000070546.2, ENSRNOT00000077481.3
    Conserved Domains (3) summary
    PHA03247
    Location:54 → 268
    PHA03247; large tegument protein UL36; Provisional
    sd00039
    Location:598 → 635
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:599 → 684
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    30913263..30941305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261868.1 → XP_063117938.1  general transcription factor 3C polypeptide 2 isoform X3

  2. XM_063261864.1 → XP_063117934.1  general transcription factor 3C polypeptide 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JY75, Q5PQP7

  3. XM_063261872.1 → XP_063117942.1  general transcription factor 3C polypeptide 2 isoform X7

  4. XM_063261871.1 → XP_063117941.1  general transcription factor 3C polypeptide 2 isoform X6

  5. XM_063261873.1 → XP_063117943.1  general transcription factor 3C polypeptide 2 isoform X8

  6. XM_063261866.1 → XP_063117936.1  general transcription factor 3C polypeptide 2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K679
    Related
    ENSRNOP00000073708.2, ENSRNOT00000079292.3

  7. XM_063261869.1 → XP_063117939.1  general transcription factor 3C polypeptide 2 isoform X4

  8. XM_063261867.1 → XP_063117937.1  general transcription factor 3C polypeptide 2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K679

  9. XM_039112172.2 → XP_038968100.1  general transcription factor 3C polypeptide 2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K679, A0A8I6A405
    Conserved Domains (3) summary
    PHA03247
    Location:54 → 295
    PHA03247; large tegument protein UL36; Provisional
    sd00039
    Location:555 → 592
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:556 → 641
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  10. XM_039112170.2 → XP_038968098.1  general transcription factor 3C polypeptide 2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K679, A0A8I6A405
    Conserved Domains (3) summary
    PHA03247
    Location:54 → 295
    PHA03247; large tegument protein UL36; Provisional
    sd00039
    Location:555 → 592
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:556 → 641
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  11. XM_063261870.1 → XP_063117940.1  general transcription factor 3C polypeptide 2 isoform X4

  12. XM_063261865.1 → XP_063117935.1  general transcription factor 3C polypeptide 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JY75, Q5PQP7

  13. XM_039112168.2 → XP_038968096.1  general transcription factor 3C polypeptide 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JY75, A0A8I6A405, Q5PQP7
    Conserved Domains (3) summary
    PHA03247
    Location:54 → 268
    PHA03247; large tegument protein UL36; Provisional
    sd00039
    Location:598 → 635
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:599 → 684
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  14. XM_039112169.2 → XP_038968097.1  general transcription factor 3C polypeptide 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JY75, A0A8I6A405, Q5PQP7
    Conserved Domains (3) summary
    PHA03247
    Location:54 → 268
    PHA03247; large tegument protein UL36; Provisional
    sd00039
    Location:598 → 635
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:599 → 684
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  15. XM_039112173.2 → XP_038968101.1  general transcription factor 3C polypeptide 2 isoform X5

    Conserved Domains (2) summary
    sd00039
    Location:265 → 302
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:266 → 351
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein Strain
Heading Accession and Version

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