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Asxl2 ASXL transcriptional regulator 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313922, updated on 2-Nov-2024

Summary

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Official Symbol
Asxl2provided by RGD
Official Full Name
ASXL transcriptional regulator 2provided by RGD
Primary source
RGD:1304710
See related
EnsemblRapid:ENSRNOG00000011908 AllianceGenome:RGD:1304710
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable chromatin binding activity and peroxisome proliferator activated receptor binding activity. Involved in positive regulation of lipid storage. Predicted to be located in nucleoplasm. Predicted to be part of PR-DUB complex. Orthologous to human ASXL2 (ASXL transcriptional regulator 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 128.0), Kidney (RPKM 116.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Asxl2 in Genome Data Viewer
Location:
6q14
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (32090497..32234487)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (26425017..26514899)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (27835346..27919285)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene RAB10, member RAS oncogene family Neighboring gene uncharacterized LOC120103491 Neighboring gene uncharacterized LOC120103492 Neighboring gene kinesin family member 3C Neighboring gene small ribosomal subunit protein bS21m-like Neighboring gene RNA pseudouridine synthase D4, pseudogene 1 Neighboring gene dystrobrevin, beta Neighboring gene basic transcription factor 3, pseudogene 5 Neighboring gene uncharacterized LOC120103494 Neighboring gene DNA methyltransferase 3 alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesis. Farber CR, et al. PLoS Genet, 2011 Apr. PMID 21490954, Free PMC Article
  2. Functional conservation of Asxl2, a murine homolog for the Drosophila enhancer of trithorax and polycomb group gene Asx. Baskind HA, et al. PLoS One, 2009. PMID 19270745, Free PMC Article
  3. Reciprocal regulation of LXRα activity by ASXL1 and ASXL2 in lipogenesis. Park UH, et al. Biochem Biophys Res Commun, 2014 Jan 10. PMID 24321552
  4. Maintenance of adult cardiac function requires the chromatin factor Asxl2. Lai HL, et al. J Mol Cell Cardiol, 2012 Nov. PMID 23046516, Free PMC Article
  5. Additional sex comb-like (ASXL) proteins 1 and 2 play opposite roles in adipogenesis via reciprocal regulation of peroxisome proliferator-activated receptor {gamma}. Park UH, et al. J Biol Chem, 2011 Jan 14. PMID 21047783, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peroxisome proliferator activated receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peroxisome proliferator activated receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adult heart development ISO
Inferred from Sequence Orthology
more info
  
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of bone mineralization involved in bone maturation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heart morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of macrophage differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of bone mineralization involved in bone maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of macrophage differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transferase activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of PR-DUB complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ASXL transcriptional regulator 2; putative Polycomb group protein ASXL2
Names
additional sex combs like 2, transcriptional regulator
additional sex combs like transcriptional regulator 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    32090497..32234487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262612.1 → XP_063118682.1  putative Polycomb group protein ASXL2 isoform X3

  2. XM_063262610.1 → XP_063118680.1  putative Polycomb group protein ASXL2 isoform X1

    Related
    ENSRNOP00000081020.2, ENSRNOT00000105980.2

  3. XM_063262611.1 → XP_063118681.1  putative Polycomb group protein ASXL2 isoform X2

    Related
    ENSRNOP00000015827.9, ENSRNOT00000015827.10

  4. XM_063262613.1 → XP_063118683.1  putative Polycomb group protein ASXL2 isoform X3

  5. XM_063262617.1 → XP_063118687.1  putative Polycomb group protein ASXL2 isoform X4

  6. XM_063262616.1 → XP_063118686.1  putative Polycomb group protein ASXL2 isoform X4

  7. XM_063262615.1 → XP_063118685.1  putative Polycomb group protein ASXL2 isoform X4

  8. XM_063262614.1 → XP_063118684.1  putative Polycomb group protein ASXL2 isoform X4

  9. XM_063262618.1 → XP_063118688.1  putative Polycomb group protein ASXL2 isoform X4

  10. XM_063262619.1 → XP_063118689.1  putative Polycomb group protein ASXL2 isoform X5

  11. XM_063262620.1 → XP_063118690.1  putative Polycomb group protein ASXL2 isoform X6

RNA

  1. XR_010052213.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108011.1: Suppressed sequence

    Description
    NM_001108011.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from chicken: ASXL2 (GeneID:421993).
Nucleotide Protein Strain
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