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Trib2 tribbles pseudokinase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313974, updated on 14-Nov-2024

Summary

Symbol
Trib2provided by RGD
Full Name
tribbles pseudokinase 2provided by RGD
Primary source
RGD:1564451
See related
EnsemblRapid:ENSRNOG00000004110 AllianceGenome:RGD:1564451
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564451
Summary
Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; ubiquitin protein ligase binding activity; and ubiquitin-protein transferase regulator activity. Predicted to be involved in negative regulation of fat cell differentiation; negative regulation of interleukin-10 production; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Orthologous to human TRIB2 (tribbles pseudokinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 209.8), Kidney (RPKM 149.4) and 9 other tissues See more
Orthologs
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Genomic context

See Trib2 in Genome Data Viewer
Location:
6q16
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (44274762..44299139, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (38545971..38570349, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (41016722..41040972, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555705 Neighboring gene uncharacterized LOC120103518 Neighboring gene uncharacterized LOC134479345 Neighboring gene uncharacterized LOC102555864

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables mitogen-activated protein kinase kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
NOT enables nucleotide binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
NOT enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase regulator activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108015.3NP_001101485.2  tribbles homolog 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8J8XB91, A6HAS1
    Related
    ENSRNOP00000005774.6, ENSRNOT00000005774.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    44274762..44299139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112192.2XP_038968120.1  tribbles homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A8J8XB91, A6HAS1
    Conserved Domains (1) summary
    cd14022
    Location:67308
    PK_TRB2; Pseudokinase domain of Tribbles Homolog 2
  2. XM_039112193.2XP_038968121.1  tribbles homolog 2 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:67187
    PKc_like; Protein Kinases, catalytic domain
  3. XM_039112194.2XP_038968122.1  tribbles homolog 2 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:67187
    PKc_like; Protein Kinases, catalytic domain