Lpin1 lipin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lpin1provided by RGD
Official Full Name: lipin 1provided by RGD
Primary source: RGD:1307646
See related: EnsemblRapid:ENSRNOG00000004377 AllianceGenome:RGD:1307646
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including histone deacetylase binding activity; peroxisome proliferator activated receptor binding activity; and phosphatidate phosphatase activity. Involved in several processes, including cellular response to insulin stimulus; negative regulation of myelination; and negative regulation of phosphatidic acid biosynthetic process. Predicted to be located in cytoplasm and nuclear membrane. Predicted to be part of transcription regulator complex. Predicted to be active in several cellular components, including cytosol; endoplasmic reticulum membrane; and mitochondrial outer membrane. Biomarker of end stage renal disease. Orthologous to human LPIN1 (lipin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 247.8), Heart (RPKM 187.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q16

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (45039110..45145845, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (39309198..39417034, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (41796214..41905149, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphatidate phosphatase Lipin1 involves in diabetic encephalopathy pathogenesis via regulating synaptic mitochondrial dynamics.
Title: Phosphatidate phosphatase Lipin1 involves in diabetic encephalopathy pathogenesis via regulating synaptic mitochondrial dynamics.
Low-Intensity Exercise Affects Cardiac Fatty Acid Oxidation by Increasing the Nuclear Content of PPARalpha, FOXO1, and Lipin1 in Fructose-Fed Rats.
Title: Low-Intensity Exercise Affects Cardiac Fatty Acid Oxidation by Increasing the Nuclear Content of PPARα, FOXO1, and Lipin1 in Fructose-Fed Rats.
Lipin1 Alleviates Autophagy Disorder in Sciatic Nerve and Improves Diabetic Peripheral Neuropathy.
Title: Lipin1 Alleviates Autophagy Disorder in Sciatic Nerve and Improves Diabetic Peripheral Neuropathy.
Lipin1 Is Involved in the Pathogenesis of Diabetic Encephalopathy through the PKD/Limk/Cofilin Signaling Pathway.
Title: Lipin1 Is Involved in the Pathogenesis of Diabetic Encephalopathy through the PKD/Limk/Cofilin Signaling Pathway.
Increase in plasma membrane FAT/CD36 content in obese rats and failure in lipin-1 export to nucleus with progression of obesity, implying an increase in FA uptake and their different channeling into lipid intermediates synthesis pathway in old fa/fa rats versus FA usage in lean rats of the same age.
Title: Obesity- and age-related alterations in FAT/CD36 translocation and lipin-1 subcellular localization in skeletal muscle of the Zucker rats.
Total expression of lipin 1 in cardiac cell lysate and its cytosolic and microsomal level were increased in the hearts of male fructose-fed rats(FFR).
Title: Gender differences in the expression and cellular localization of lipin 1 in the hearts of fructose-fed rats.
novel differences in the regulation of lipins 1,2,3, PPARalpha, and PGC-1alpha splice variants during fasting in heart versus liver, even though the ultimate outcome in both tissues is to increase FA turnover and oxidation.
Title: Differential regulation of the expressions of the PGC-1α splice variants, lipins, and PPARα in heart compared to liver.
The decrease in lipin1 expression and AMPKalpha activation may contribute to hepatic insulin resistance in diet-induced obese rats.
Title: Expression and significance of lipin1 and AMPKα in hepatic insulin resistance in diet-induced insulin resistance rats.
Estrogen-related receptor gamma (ERRgamma) is a novel transcriptional regulator of phosphatidic acid phosphatase, LIPIN1, and inhibits hepatic insulin signaling
Title: Estrogen-related receptor γ (ERRγ) is a novel transcriptional regulator of phosphatidic acid phosphatase, LIPIN1, and inhibits hepatic insulin signaling.
A hypomorphic mutation in Lpin1 induces progressively improving neuropathy and lipodystrophy in the rat
Title: A hypomorphic mutation in Lpin1 induces progressively improving neuropathy and lipodystrophy in the rat.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables peroxisome proliferator activated receptor binding	ISO Inferred from Sequence Orthology more info
enables phosphatidate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in fatty acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phosphatidic acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in phosphatidic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylethanolamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ruffle organization	ISO Inferred from Sequence Orthology more info
involved_in triglyceride biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride mobilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosphatidate phosphatase LPIN1

NP_001012111.1

EC 3.1.3.4

XP_038968123.1

EC 3.1.3.4

XP_038968124.1

EC 3.1.3.4

XP_038968125.1

EC 3.1.3.4

XP_038968127.1

EC 3.1.3.4

XP_038968128.1

EC 3.1.3.4

XP_038968129.1

EC 3.1.3.4

XP_038968130.1

EC 3.1.3.4

XP_038968131.1

EC 3.1.3.4

XP_038968132.1

EC 3.1.3.4

XP_063117955.1

EC 3.1.3.4

XP_063117956.1

EC 3.1.3.4

XP_063117958.1

EC 3.1.3.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012111.1 → NP_001012111.1 phosphatidate phosphatase LPIN1

See identical proteins and their annotated locations for NP_001012111.1

Status: VALIDATED

Source sequence(s)

BC083651

UniProtKB/TrEMBL

A6HAS7, Q5XIM8

Related

ENSRNOP00000005863.6, ENSRNOT00000005863.8

Conserved Domains (4) summary

pfam15017
Location:889 → 918

AF1Q; Drug resistance and apoptosis regulator

pfam04571
Location:1 → 106

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:660 → 885

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:498 → 588

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

45039110..45145845 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039112199.2 → XP_038968127.1 phosphatidate phosphatase LPIN1 isoform X4

UniProtKB/TrEMBL

A6HAS7

Conserved Domains (3) summary

pfam04571
Location:50 → 156

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:708 → 933

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:546 → 637

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_039112197.2 → XP_038968125.1 phosphatidate phosphatase LPIN1 isoform X3

UniProtKB/TrEMBL

A0A0G2JW03, A6HAS6, A6HAS7

Conserved Domains (3) summary

pfam04571
Location:50 → 156

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:709 → 934

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:547 → 638

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_039112195.2 → XP_038968123.1 phosphatidate phosphatase LPIN1 isoform X1

UniProtKB/TrEMBL

A6HAS7

Conserved Domains (3) summary

pfam04571
Location:50 → 156

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:735 → 960

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:547 → 664

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_039112200.2 → XP_038968128.1 phosphatidate phosphatase LPIN1 isoform X5

UniProtKB/TrEMBL

A6HAS7

Conserved Domains (3) summary

pfam04571
Location:50 → 156

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:702 → 927

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:514 → 631

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_039112196.2 → XP_038968124.1 phosphatidate phosphatase LPIN1 isoform X2

UniProtKB/TrEMBL

A6HAS7

Conserved Domains (3) summary

pfam04571
Location:50 → 156

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:734 → 959

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:546 → 663

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_039112203.2 → XP_038968131.1 phosphatidate phosphatase LPIN1 isoform X8

UniProtKB/TrEMBL

A0A8I5ZPU6, A6HAS7

Related

ENSRNOP00000080344.1, ENSRNOT00000114735.2

Conserved Domains (3) summary

pfam04571
Location:50 → 156

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:676 → 901

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:514 → 605

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_063261885.1 → XP_063117955.1 phosphatidate phosphatase LPIN1 isoform X7
XM_039112201.2 → XP_038968129.1 phosphatidate phosphatase LPIN1 isoform X6

UniProtKB/TrEMBL

A6HAS7, F7FDH2

Conserved Domains (3) summary

pfam04571
Location:1 → 107

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:686 → 911

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:498 → 615

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_039112202.2 → XP_038968130.1 phosphatidate phosphatase LPIN1 isoform X6

UniProtKB/TrEMBL

A6HAS7, F7FDH2

Conserved Domains (3) summary

pfam04571
Location:1 → 107

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:686 → 911

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:498 → 615

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_063261888.1 → XP_063117958.1 phosphatidate phosphatase LPIN1 isoform X10

UniProtKB/TrEMBL

Q5XIM8
XM_039112204.2 → XP_038968132.1 phosphatidate phosphatase LPIN1 isoform X11

Conserved Domains (2) summary

pfam08235
Location:464 → 689

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:276 → 393

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_063261886.1 → XP_063117956.1 phosphatidate phosphatase LPIN1 isoform X9