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Cbll1 Cbl proto-oncogene like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314028, updated on 10-Jul-2024

Summary

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Official Symbol
Cbll1provided by RGD
Official Full Name
Cbl proto-oncogene like 1provided by RGD
Primary source
RGD:1310703
See related
EnsemblRapid:ENSRNOG00000007253 AllianceGenome:RGD:1310703
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including cell-cell adhesion; mRNA methylation; and protein ubiquitination. Predicted to act upstream of or within negative regulation of cell adhesion; positive regulation of cell migration; and positive regulation of endocytosis. Predicted to be located in cytoplasm and nuclear speck. Predicted to be part of RNA N6-methyladenosine methyltransferase complex. Orthologous to human CBLL1 (Cbl proto-oncogene like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 86.0), Spleen (RPKM 76.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cbll1 in Genome Data Viewer
Location:
6q16
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (53798712..53812890, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (48071190..48086174, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (50772718..50786861, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene dihydrolipoamide dehydrogenase Neighboring gene solute carrier family 26 member 3 Neighboring gene uncharacterized LOC102555378 Neighboring gene solute carrier family 26 member 4 Neighboring gene uncharacterized LOC108351220

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Fujita Y, et al. Nat Cell Biol, 2002 Mar. PMID 11836526
  2. Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin. Mukherjee M, et al. EMBO J, 2012 Mar 7. PMID 22252131, Free PMC Article
  3. Zc3h13 Regulates Nuclear RNA m(6)A Methylation and Mouse Embryonic Stem Cell Self-Renewal. Wen J, et al. Mol Cell, 2018 Mar 15. PMID 29547716, Free PMC Article
  4. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA N6-methyladenosine methyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase Hakai
Names
Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
Casitas B-lineage lymphoma-like 1
Cbl proto-oncogene, E3 ubiquitin protein ligase-like 1
Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
NP_001101488.1
NP_001386492.1
NP_001386493.1
XP_006240050.1
XP_038968140.1
XP_038968141.1
XP_038968142.1
XP_038968144.1
XP_038968146.1
XP_063117967.1
XP_063117968.1
XP_063117969.1
XP_063117970.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108018.1 → NP_001101488.1  E3 ubiquitin-protein ligase Hakai isoform 3

    See identical proteins and their annotated locations for NP_001101488.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473947
    UniProtKB/TrEMBL
    A6HB48, D3ZS02
    Related
    ENSRNOP00000094608.2, ENSRNOT00000102801.2
    Conserved Domains (1) summary
    pfam13923
    Location:106 → 145
    zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

  2. NM_001399563.1 → NP_001386492.1  E3 ubiquitin-protein ligase Hakai isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    D3ZS02
    Related
    ENSRNOP00000009565.5, ENSRNOT00000009566.6

  3. NM_001399564.1 → NP_001386493.1  E3 ubiquitin-protein ligase Hakai isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    D3ZS02

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    53798712..53812890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239988.5 → XP_006240050.1  E3 ubiquitin-protein ligase Hakai isoform X5

    UniProtKB/TrEMBL
    D3ZS02
    Conserved Domains (1) summary
    pfam13923
    Location:105 → 144
    zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

  2. XM_063261900.1 → XP_063117970.1  E3 ubiquitin-protein ligase Hakai isoform X9

    UniProtKB/TrEMBL
    A0A8I6AJZ8

  3. XM_063261899.1 → XP_063117969.1  E3 ubiquitin-protein ligase Hakai isoform X8

    UniProtKB/TrEMBL
    A0A8I6AJZ8

  4. XM_063261898.1 → XP_063117968.1  E3 ubiquitin-protein ligase Hakai isoform X7

    UniProtKB/TrEMBL
    A0A8I6AJZ8

  5. XM_039112218.2 → XP_038968146.1  E3 ubiquitin-protein ligase Hakai isoform X6

    UniProtKB/TrEMBL
    A0A8I6AJZ8
    Conserved Domains (2) summary
    cd16508
    Location:57 → 98
    RING-HC_HAKAI_like; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Hakai, zinc finger protein 645 (ZNF645), and similar proteins
    pfam18408
    Location:111 → 142
    zf_Hakai; C2H2 Hakai zinc finger domain

  6. XM_039112214.2 → XP_038968142.1  E3 ubiquitin-protein ligase Hakai isoform X4

    UniProtKB/TrEMBL
    D3ZS02
    Related
    ENSRNOP00000100923.1, ENSRNOT00000141682.1
    Conserved Domains (2) summary
    cd16508
    Location:155 → 196
    RING-HC_HAKAI_like; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Hakai, zinc finger protein 645 (ZNF645), and similar proteins
    pfam18408
    Location:209 → 240
    zf_Hakai; C2H2 Hakai zinc finger domain

  7. XM_063261897.1 → XP_063117967.1  E3 ubiquitin-protein ligase Hakai isoform X6

    UniProtKB/TrEMBL
    A0A8I6AJZ8

  8. XM_039112216.2 → XP_038968144.1  E3 ubiquitin-protein ligase Hakai isoform X3

    UniProtKB/TrEMBL
    D3ZS02
    Conserved Domains (2) summary
    cd16508
    Location:154 → 195
    RING-HC_HAKAI_like; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Hakai, zinc finger protein 645 (ZNF645), and similar proteins
    pfam18408
    Location:208 → 239
    zf_Hakai; C2H2 Hakai zinc finger domain

  9. XM_039112213.2 → XP_038968141.1  E3 ubiquitin-protein ligase Hakai isoform X2

    UniProtKB/TrEMBL
    D3ZS02
    Conserved Domains (2) summary
    cd16508
    Location:157 → 198
    RING-HC_HAKAI_like; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Hakai, zinc finger protein 645 (ZNF645), and similar proteins
    pfam18408
    Location:211 → 242
    zf_Hakai; C2H2 Hakai zinc finger domain

  10. XM_039112212.2 → XP_038968140.1  E3 ubiquitin-protein ligase Hakai isoform X1

    UniProtKB/TrEMBL
    D3ZS02
    Conserved Domains (2) summary
    cd16508
    Location:158 → 199
    RING-HC_HAKAI_like; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Hakai, zinc finger protein 645 (ZNF645), and similar proteins
    pfam18408
    Location:212 → 243
    zf_Hakai; C2H2 Hakai zinc finger domain
Nucleotide Protein Strain
Heading Accession and Version

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