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Klhl15 kelch-like family member 15 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314111, updated on 2-Nov-2024

Summary

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Official Symbol
Klhl15provided by RGD
Official Full Name
kelch-like family member 15provided by RGD
Primary source
RGD:1563101
See related
EnsemblRapid:ENSRNOG00000006515 AllianceGenome:RGD:1563101
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563101
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in negative regulation of double-strand break repair via homologous recombination and nuclear protein quality control by the ubiquitin-proteasome system. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 103. Orthologous to human KLHL15 (kelch like family member 15). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 61.1), Thymus (RPKM 51.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Klhl15 in Genome Data Viewer
Location:
Xq22
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (62987762..63043980)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (58994726..59050207)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (63342277..63390915)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA21 Neighboring gene eukaryotic translation elongation factor 1 gamma, pseudogene 14 Neighboring gene solute carrier family 25 member 21, pseudogene 1 Neighboring gene similar to human chromosome X open reading frame 58

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection. Ferretti LP, et al. Nat Commun, 2016 Aug 26. PMID 27561354, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC189229

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in negative regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of double-strand break repair via homologous recombination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nuclear protein quality control by the ubiquitin-proteasome system IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear protein quality control by the ubiquitin-proteasome system ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear protein quality control by the ubiquitin-proteasome system ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul3-RING ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
kelch-like protein 15
Names
kelch-like 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108021.2 → NP_001101491.1  kelch-like protein 15

    See identical proteins and their annotated locations for NP_001101491.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/Swiss-Prot
    D3ZA50
    Conserved Domains (4) summary
    PHA03098
    Location:33 → 576
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:417 → 474
    Kelch; KELCH repeat [structural motif]
    cd18244
    Location:1 → 137
    BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
    cd18454
    Location:128 → 235
    BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

  2. NM_001434052.1 → NP_001420981.1  kelch-like protein 15

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

  3. NM_001434053.1 → NP_001420982.1  kelch-like protein 15

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

  4. NM_001434054.1 → NP_001420983.1  kelch-like protein 15

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

  5. NM_001434055.1 → NP_001420984.1  kelch-like protein 15

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

  6. NM_001434057.1 → NP_001420986.1  kelch-like protein 15

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

  7. NM_001434058.1 → NP_001420987.1  kelch-like protein 15

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    62987762..63043980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017602042.3 → XP_017457531.1  kelch-like protein 15 isoform X1

    UniProtKB/Swiss-Prot
    D3ZA50
    Conserved Domains (4) summary
    PHA03098
    Location:33 → 576
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:417 → 474
    Kelch; KELCH repeat [structural motif]
    cd18244
    Location:1 → 137
    BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
    cd18454
    Location:128 → 235
    BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

  2. XM_063280000.1 → XP_063136070.1  kelch-like protein 15 isoform X1

    UniProtKB/Swiss-Prot
    D3ZA50

  3. XM_063279995.1 → XP_063136065.1  kelch-like protein 15 isoform X1

    UniProtKB/Swiss-Prot
    D3ZA50

  4. XM_063279999.1 → XP_063136069.1  kelch-like protein 15 isoform X1

    UniProtKB/Swiss-Prot
    D3ZA50

  5. XM_063280003.1 → XP_063136073.1  kelch-like protein 15 isoform X4

  6. XM_063280004.1 → XP_063136074.1  kelch-like protein 15 isoform X5

  7. XM_063279994.1 → XP_063136064.1  kelch-like protein 15 isoform X1

    UniProtKB/Swiss-Prot
    D3ZA50
    Related
    ENSRNOP00000008558.5, ENSRNOT00000008558.7

  8. XM_039099706.2 → XP_038955634.1  kelch-like protein 15 isoform X1

    UniProtKB/Swiss-Prot
    D3ZA50
    Conserved Domains (4) summary
    PHA03098
    Location:33 → 576
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:417 → 474
    Kelch; KELCH repeat [structural motif]
    cd18244
    Location:1 → 137
    BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
    cd18454
    Location:128 → 235
    BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

  9. XM_063279997.1 → XP_063136067.1  kelch-like protein 15 isoform X1

    UniProtKB/Swiss-Prot
    D3ZA50

  10. XM_063279998.1 → XP_063136068.1  kelch-like protein 15 isoform X1

    UniProtKB/Swiss-Prot
    D3ZA50

  11. XM_039099705.2 → XP_038955633.1  kelch-like protein 15 isoform X1

    UniProtKB/Swiss-Prot
    D3ZA50
    Conserved Domains (4) summary
    PHA03098
    Location:33 → 576
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:417 → 474
    Kelch; KELCH repeat [structural motif]
    cd18244
    Location:1 → 137
    BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
    cd18454
    Location:128 → 235
    BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

  12. XM_063279996.1 → XP_063136066.1  kelch-like protein 15 isoform X1

    UniProtKB/Swiss-Prot
    D3ZA50

  13. XM_017602041.3 → XP_017457530.1  kelch-like protein 15 isoform X1

    UniProtKB/Swiss-Prot
    D3ZA50
    Conserved Domains (4) summary
    PHA03098
    Location:33 → 576
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:417 → 474
    Kelch; KELCH repeat [structural motif]
    cd18244
    Location:1 → 137
    BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
    cd18454
    Location:128 → 235
    BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

  14. XM_063279993.1 → XP_063136063.1  kelch-like protein 15 isoform X1

    UniProtKB/Swiss-Prot
    D3ZA50

  15. XM_063280001.1 → XP_063136071.1  kelch-like protein 15 isoform X2

  16. XM_063279992.1 → XP_063136062.1  kelch-like protein 15 isoform X1

    UniProtKB/Swiss-Prot
    D3ZA50

  17. XM_063280002.1 → XP_063136072.1  kelch-like protein 15 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZA50.1 GenPept UniProtKB/Swiss-Prot:D3ZA50

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