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Baz1a bromodomain adjacent to zinc finger domain, 1A [ Rattus norvegicus (Norway rat) ]

Gene ID: 314126, updated on 2-Nov-2024

Summary

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Official Symbol
Baz1aprovided by RGD
Official Full Name
bromodomain adjacent to zinc finger domain, 1Aprovided by RGD
Primary source
RGD:1306199
See related
EnsemblRapid:ENSRNOG00000006828 AllianceGenome:RGD:1306199
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA binding activity. Predicted to be involved in several processes, including nucleosome assembly; positive regulation of DNA replication; and regulation of gene expression. Predicted to be located in nucleus and pericentric heterochromatin. Predicted to be part of ACF complex and CHRAC. Predicted to be active in nuclear chromosome. Orthologous to human BAZ1A (bromodomain adjacent to zinc finger domain 1A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 234.1), Spleen (RPKM 151.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Baz1a in Genome Data Viewer
Location:
6q23
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (78124872..78247672, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (72389701..72512516, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (75793223..75873854, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene cofilin 2 Neighboring gene uncharacterized LOC108351236 Neighboring gene U6 spliceosomal RNA Neighboring gene RIKEN cDNA 2700097009 gene like Neighboring gene signal recognition particle 54A Neighboring gene uncharacterized LOC134479210 Neighboring gene family with sequence similarity 177, member A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin. Collins N, et al. Nat Genet, 2002 Dec. PMID 12434153
  2. HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins. Poot RA, et al. EMBO J, 2000 Jul 3. PMID 10880450, Free PMC Article
  3. Capturing novel mouse genes encoding chromosomal and other nuclear proteins. Tate P, et al. J Cell Sci, 1998 Sep. PMID 9701556
  4. ATP-dependent chromatin remodeling: genetics, genomics and mechanisms. Hargreaves DC, et al. Cell Res, 2011 Mar. PMID 21358755, Free PMC Article
  5. Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Sutherland HG, et al. Hum Mol Genet, 2001 Sep 1. PMID 11555636

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of ACF complex ISO
Inferred from Sequence Orthology
more info
  
part_of CHRAC IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CHRAC ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in pericentric heterochromatin ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
bromodomain adjacent to zinc finger domain protein 1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170568.2 → NP_001164039.2  bromodomain adjacent to zinc finger domain protein 1A

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    F1M4U9
    Related
    ENSRNOP00000009080.7, ENSRNOT00000009080.9
    Conserved Domains (7) summary
    cd05504
    Location:1419 → 1532
    Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...
    PTZ00121
    Location:646 → 793
    PTZ00121; MAEBL; Provisional
    smart00571
    Location:422 → 483
    DDT; domain in different transcription and chromosome remodeling factors
    cd15627
    Location:1147 → 1192
    PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)
    pfam10537
    Location:23 → 122
    WAC_Acf1_DNA_bd; ATP-utilising chromatin assembly and remodelling N-terminal
    pfam15612
    Location:590 → 635
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
    pfam15613
    Location:799 → 925
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    78124872..78247672 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261906.1 → XP_063117976.1  bromodomain adjacent to zinc finger domain protein 1A isoform X2

  2. XM_039112223.2 → XP_038968151.1  bromodomain adjacent to zinc finger domain protein 1A isoform X1

    Conserved Domains (7) summary
    cd05504
    Location:1449 → 1562
    Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...
    PTZ00121
    Location:646 → 793
    PTZ00121; MAEBL; Provisional
    smart00571
    Location:422 → 483
    DDT; domain in different transcription and chromosome remodeling factors
    cd15627
    Location:1177 → 1222
    PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)
    pfam10537
    Location:23 → 122
    WAC_Acf1_DNA_bd; ATP-utilising chromatin assembly and remodelling N-terminal
    pfam15612
    Location:590 → 635
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
    pfam15613
    Location:799 → 925
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

  3. XM_063261908.1 → XP_063117978.1  bromodomain adjacent to zinc finger domain protein 1A isoform X3

    UniProtKB/TrEMBL
    A0A8I6G4X5

  4. XM_063261907.1 → XP_063117977.1  bromodomain adjacent to zinc finger domain protein 1A isoform X3

    UniProtKB/TrEMBL
    A0A8I6G4X5
    Related
    ENSRNOP00000079177.1, ENSRNOT00000098593.2

  5. XM_063261905.1 → XP_063117975.1  bromodomain adjacent to zinc finger domain protein 1A isoform X2

  6. XM_039112222.2 → XP_038968150.1  bromodomain adjacent to zinc finger domain protein 1A isoform X1

    Conserved Domains (7) summary
    cd05504
    Location:1449 → 1562
    Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...
    PTZ00121
    Location:646 → 793
    PTZ00121; MAEBL; Provisional
    smart00571
    Location:422 → 483
    DDT; domain in different transcription and chromosome remodeling factors
    cd15627
    Location:1177 → 1222
    PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)
    pfam10537
    Location:23 → 122
    WAC_Acf1_DNA_bd; ATP-utilising chromatin assembly and remodelling N-terminal
    pfam15612
    Location:590 → 635
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
    pfam15613
    Location:799 → 925
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

  7. XM_039112224.2 → XP_038968152.1  bromodomain adjacent to zinc finger domain protein 1A isoform X2

    Conserved Domains (7) summary
    cd05504
    Location:1417 → 1530
    Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...
    PTZ00121
    Location:614 → 761
    PTZ00121; MAEBL; Provisional
    smart00571
    Location:422 → 483
    DDT; domain in different transcription and chromosome remodeling factors
    cd15627
    Location:1145 → 1190
    PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)
    pfam10537
    Location:23 → 122
    WAC_Acf1_DNA_bd; ATP-utilising chromatin assembly and remodelling N-terminal
    pfam15612
    Location:558 → 603
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
    pfam15613
    Location:767 → 893
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

  8. XM_039112225.2 → XP_038968153.1  bromodomain adjacent to zinc finger domain protein 1A isoform X3

    UniProtKB/TrEMBL
    A0A8I6G4X5
    Conserved Domains (7) summary
    cd05504
    Location:1387 → 1500
    Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...
    PTZ00121
    Location:614 → 761
    PTZ00121; MAEBL; Provisional
    smart00571
    Location:422 → 483
    DDT; domain in different transcription and chromosome remodeling factors
    cd15627
    Location:1115 → 1160
    PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)
    pfam10537
    Location:23 → 122
    WAC_Acf1_DNA_bd; ATP-utilising chromatin assembly and remodelling N-terminal
    pfam15612
    Location:558 → 603
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
    pfam15613
    Location:767 → 893
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

  9. XM_063261904.1 → XP_063117974.1  bromodomain adjacent to zinc finger domain protein 1A isoform X2

  10. XM_039112221.1 → XP_038968149.1  bromodomain adjacent to zinc finger domain protein 1A isoform X1

    Conserved Domains (7) summary
    cd05504
    Location:1449 → 1562
    Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...
    PTZ00121
    Location:646 → 793
    PTZ00121; MAEBL; Provisional
    smart00571
    Location:422 → 483
    DDT; domain in different transcription and chromosome remodeling factors
    cd15627
    Location:1177 → 1222
    PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)
    pfam10537
    Location:23 → 122
    WAC_Acf1_DNA_bd; ATP-utilising chromatin assembly and remodelling N-terminal
    pfam15612
    Location:590 → 635
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
    pfam15613
    Location:799 → 925
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

  11. XM_063261909.1 → XP_063117979.1  bromodomain adjacent to zinc finger domain protein 1A isoform X4

  12. XM_039112227.2 → XP_038968155.1  bromodomain adjacent to zinc finger domain protein 1A isoform X6

    UniProtKB/TrEMBL
    A6HBL3
    Conserved Domains (5) summary
    cd05504
    Location:933 → 1046
    Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...
    PTZ00121
    Location:130 → 277
    PTZ00121; MAEBL; Provisional
    cd15627
    Location:661 → 706
    PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)
    pfam15612
    Location:74 → 119
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
    pfam15613
    Location:283 → 409
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

  13. XM_039112226.2 → XP_038968154.1  bromodomain adjacent to zinc finger domain protein 1A isoform X5

    UniProtKB/TrEMBL
    A6HBL3
    Conserved Domains (5) summary
    cd05504
    Location:965 → 1078
    Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...
    PTZ00121
    Location:162 → 309
    PTZ00121; MAEBL; Provisional
    cd15627
    Location:693 → 738
    PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)
    pfam15612
    Location:106 → 151
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
    pfam15613
    Location:315 → 441
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
Nucleotide Protein Strain
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