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Daam1 dishevelled associated activator of morphogenesis 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314212, updated on 2-Nov-2024

Summary

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Official Symbol
Daam1provided by RGD
Official Full Name
dishevelled associated activator of morphogenesis 1provided by RGD
Primary source
RGD:1305119
See related
EnsemblRapid:ENSRNOG00000004345 AllianceGenome:RGD:1305119
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity. Involved in presynaptic actin cytoskeleton organization. Is active in glutamatergic synapse and presynapse. Orthologous to human DAAM1 (dishevelled associated activator of morphogenesis 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 129.9), Lung (RPKM 117.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Daam1 in Genome Data Viewer
Location:
6q24
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (96125521..96286049)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (90389544..90550114)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (94606675..94739026)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093260 Neighboring gene uncharacterized LOC108351250 Neighboring gene large ribosomal subunit protein eL15-like Neighboring gene uncharacterized LOC120103547 Neighboring gene G protein-coupled receptor 135

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. D-Aspartate Upregulates DAAM1 Protein Levels in the Rat Testis and Induces Its Localization in Spermatogonia Nucleus. Venditti M, et al. Biomolecules, 2020 Apr 28. PMID 32353957, Free PMC Article
  2. Involvement of testicular DAAM1 expression in zinc protection against cadmium-induced male rat reproductive toxicity. Chemek M, et al. J Cell Physiol, 2018 Jan. PMID 28332181
  3. First Evidence of DAAM1 Localization During the Post-Natal Development of Rat Testis and in Mammalian Sperm. Pariante P, et al. J Cell Physiol, 2016 Oct. PMID 26831620
  4. Piccolo Directs Activity Dependent F-Actin Assembly from Presynaptic Active Zones via Daam1. Wagh D, et al. PLoS One, 2015. PMID 25897839, Free PMC Article
  5. Localization of the Diaphanous-related formin Daam1 to neuronal dendrites. Salomon SN, et al. Neurosci Lett, 2008 Dec 5. PMID 18832009

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. D-Aspartate Upregulates DAAM1 Protein Levels in the Rat Testis and Induces Its Localization in Spermatogonia Nucleus.
    Title: D-Aspartate Upregulates DAAM1 Protein Levels in the Rat Testis and Induces Its Localization in Spermatogonia Nucleus.
  2. Zinc chloride could prevent cadmium chloride-induced testicular toxicity and sperm quality alteration in adult male rat after gestational and lactational exposure, probably via the restoration of the testicular DAAM1 expression inhibited by Cd.
    Title: Involvement of testicular DAAM1 expression in zinc protection against cadmium-induced male rat reproductive toxicity.
  3. a role for DAAM1 in cytoskeletal organization during Mammalian testis morphogenesis and gamete progression
    Title: First Evidence of DAAM1 Localization During the Post-Natal Development of Rat Testis and in Mammalian Sperm.
  4. Similar to Piccolo and Profilin, Daam1 loss of function impairs presynaptic-F-actin assembly in neurons.
    Title: Piccolo Directs Activity Dependent F-Actin Assembly from Presynaptic Active Zones via Daam1.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in presynaptic actin cytoskeleton organization EXP
Inferred from Experiment
more info
 PubMed 
involved_in presynaptic actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in presynaptic actin cytoskeleton organization IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in presynaptic actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
disheveled-associated activator of morphogenesis 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108030.1 → NP_001101500.1  disheveled-associated activator of morphogenesis 1 isoform 1

    See identical proteins and their annotated locations for NP_001101500.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473947
    UniProtKB/TrEMBL
    A0A8I5Y0A6, A6HC27, D4ABM3
    Related
    ENSRNOP00000005846.4, ENSRNOT00000005846.6
    Conserved Domains (4) summary
    pfam02181
    Location:512 → 873
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:235 → 439
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:45 → 232
    Drf_GBD; Diaphanous GTPase-binding Domain
    pfam10211
    Location:450 → 507
    Ax_dynein_light; Axonemal dynein light chain

  2. NM_001433960.1 → NP_001420889.1  disheveled-associated activator of morphogenesis 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  3. NM_001433961.1 → NP_001420890.1  disheveled-associated activator of morphogenesis 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  4. NM_001433962.1 → NP_001420891.1  disheveled-associated activator of morphogenesis 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  5. NM_001433963.1 → NP_001420892.1  disheveled-associated activator of morphogenesis 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  6. NM_001433964.1 → NP_001420893.1  disheveled-associated activator of morphogenesis 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  7. NM_001433965.1 → NP_001420894.1  disheveled-associated activator of morphogenesis 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    96125521..96286049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261925.1 → XP_063117995.1  disheveled-associated activator of morphogenesis 1 isoform X2

    Related
    ENSRNOP00000100888.1, ENSRNOT00000162986.1

  2. XM_039112262.2 → XP_038968190.1  disheveled-associated activator of morphogenesis 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y0A6, A0A8I6GM04
    Conserved Domains (4) summary
    PRK12704
    Location:444 → 513
    PRK12704; phosphodiesterase; Provisional
    pfam06367
    Location:235 → 439
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:600 → 983
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:45 → 232
    Drf_GBD; Diaphanous GTPase-binding Domain

  3. XM_063261924.1 → XP_063117994.1  disheveled-associated activator of morphogenesis 1 isoform X2

    Related
    ENSRNOP00000107911.1, ENSRNOT00000137984.1

  4. XM_039112260.2 → XP_038968188.1  disheveled-associated activator of morphogenesis 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y0A6, A0A8I6GM04
    Related
    ENSRNOP00000096283.1, ENSRNOT00000110744.2
    Conserved Domains (4) summary
    PRK12704
    Location:444 → 513
    PRK12704; phosphodiesterase; Provisional
    pfam06367
    Location:235 → 439
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:600 → 983
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:45 → 232
    Drf_GBD; Diaphanous GTPase-binding Domain

  5. XM_039112265.2 → XP_038968193.1  disheveled-associated activator of morphogenesis 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y0A6
    Conserved Domains (4) summary
    PRK12704
    Location:444 → 513
    PRK12704; phosphodiesterase; Provisional
    pfam06367
    Location:235 → 439
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:600 → 973
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:45 → 232
    Drf_GBD; Diaphanous GTPase-binding Domain

  6. XM_039112261.2 → XP_038968189.1  disheveled-associated activator of morphogenesis 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y0A6, A0A8I6GM04
    Conserved Domains (4) summary
    PRK12704
    Location:444 → 513
    PRK12704; phosphodiesterase; Provisional
    pfam06367
    Location:235 → 439
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:600 → 983
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:45 → 232
    Drf_GBD; Diaphanous GTPase-binding Domain

  7. XM_039112263.2 → XP_038968191.1  disheveled-associated activator of morphogenesis 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y0A6, A0A8I6GM04
    Conserved Domains (4) summary
    PRK12704
    Location:444 → 513
    PRK12704; phosphodiesterase; Provisional
    pfam06367
    Location:235 → 439
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:600 → 983
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:45 → 232
    Drf_GBD; Diaphanous GTPase-binding Domain

  8. XM_039112264.2 → XP_038968192.1  disheveled-associated activator of morphogenesis 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y0A6, A0A8I6GM04
    Conserved Domains (4) summary
    PRK12704
    Location:444 → 513
    PRK12704; phosphodiesterase; Provisional
    pfam06367
    Location:235 → 439
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:600 → 983
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:45 → 232
    Drf_GBD; Diaphanous GTPase-binding Domain

  9. XM_039112266.2 → XP_038968194.1  disheveled-associated activator of morphogenesis 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y0A6, A0A8I6GM04
    Conserved Domains (4) summary
    PRK12704
    Location:444 → 513
    PRK12704; phosphodiesterase; Provisional
    pfam06367
    Location:235 → 439
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:600 → 983
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:45 → 232
    Drf_GBD; Diaphanous GTPase-binding Domain
Nucleotide Protein Strain
Heading Accession and Version

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