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Galc galactosylceramidase [ Rattus norvegicus (Norway rat) ]

Gene ID: 314360, updated on 14-Nov-2024

Summary

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Official Symbol
Galcprovided by RGD
Official Full Name
galactosylceramidaseprovided by RGD
Primary source
RGD:1359384
See related
EnsemblRapid:ENSRNOG00000003759 AllianceGenome:RGD:1359384
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable galactosylceramidase activity. Predicted to be involved in galactosylceramide catabolic process. Predicted to act upstream of or within myelination. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in Krabbe disease. Orthologous to human GALC (galactosylceramidase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 273.8), Kidney (RPKM 115.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Galc in Genome Data Viewer
Location:
6q32
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (123182636..123252024, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (117452888..117522281, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (122177195..122239411, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene cofilin 1, pseudogene 1 Neighboring gene uncharacterized LOC120093266 Neighboring gene G-protein coupled receptor 65 Neighboring gene uncharacterized LOC120103597 Neighboring gene potassium two pore domain channel subfamily K member 10 Neighboring gene U7 small nuclear RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Antibodies to Protein but Not Glycolipid Structures Are Important for Host Defense against Mycoplasma pneumoniae. Meyer Sauteur PM, et al. Infect Immun, 2019 Feb. PMID 30396892, Free PMC Article
  2. Altered gene transcription linked to astrocytes and oligodendrocytes in frontal cortex in Creutzfeldt-Jakob disease. Andres Benito P, et al. Prion, 2018. PMID 30009661, Free PMC Article
  3. Intrathecal antibody responses to GalC in Guillain-Barré syndrome triggered by Mycoplasma pneumoniae. Meyer Sauteur PM, et al. J Neuroimmunol, 2018 Jan 15. PMID 29301655
  4. Mycoplasma pneumoniae triggering the Guillain-Barré syndrome: A case-control study. Meyer Sauteur PM, et al. Ann Neurol, 2016 Oct. PMID 27490360
  5. Cross-reactive anti-galactocerebroside antibodies and Mycoplasma pneumoniae infections in Guillain-Barré syndrome. Ang CW, et al. J Neuroimmunol, 2002 Sep. PMID 12225900

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables galactosylceramidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables galactosylceramidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in galactosylceramide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within galactosylceramide catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in galactosylceramide catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within myelination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
galactocerebrosidase
NP_001005888.1
XP_017449653.1
XP_038968259.1
XP_063118026.1
XP_063118027.1
XP_063118028.1
XP_063118029.1
XP_063118030.1
XP_063118031.1
XP_063118032.1
XP_063118033.1
XP_063118034.1
XP_063118035.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005888.1 → NP_001005888.1  galactocerebrosidase precursor

    See identical proteins and their annotated locations for NP_001005888.1

    Status: PROVISIONAL

    Source sequence(s)
    AY386370
    UniProtKB/TrEMBL
    A0A0G2QC23, A6JEE0, G3V6H1, Q5YKG1
    Conserved Domains (2) summary
    pfam02057
    Location:1 → 668
    Glyco_hydro_59; Glycosyl hydrolase family 59
    cl23815
    Location:16 → 297
    Glyco_hydro_30; O-Glycosyl hydrolase family 30

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    123182636..123252024 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261959.1 → XP_063118029.1  galactocerebrosidase isoform X3

  2. XM_039112331.1 → XP_038968259.1  galactocerebrosidase isoform X4

    UniProtKB/TrEMBL
    A6JEE0, G3V6H1, Q5YKG1
    Conserved Domains (2) summary
    pfam02057
    Location:1 → 233
    Glyco_hydro_59; Glycosyl hydrolase family 59
    pfam17387
    Location:241 → 357
    Glyco_hydro_59M; Glycosyl hydrolase family 59 central domain

  3. XM_063261963.1 → XP_063118033.1  galactocerebrosidase isoform X3

  4. XM_063261956.1 → XP_063118026.1  galactocerebrosidase isoform X1

    Related
    ENSRNOP00000005015.7, ENSRNOT00000005015.8

  5. XM_063261964.1 → XP_063118034.1  galactocerebrosidase isoform X3

  6. XM_017594164.3 → XP_017449653.1  galactocerebrosidase isoform X4

    UniProtKB/TrEMBL
    A6JEE0, G3V6H1, Q5YKG1
    Conserved Domains (2) summary
    pfam02057
    Location:1 → 233
    Glyco_hydro_59; Glycosyl hydrolase family 59
    pfam17387
    Location:241 → 357
    Glyco_hydro_59M; Glycosyl hydrolase family 59 central domain

  7. XM_063261958.1 → XP_063118028.1  galactocerebrosidase isoform X3

  8. XM_063261961.1 → XP_063118031.1  galactocerebrosidase isoform X3

  9. XM_063261960.1 → XP_063118030.1  galactocerebrosidase isoform X3

  10. XM_063261962.1 → XP_063118032.1  galactocerebrosidase isoform X3

  11. XM_063261957.1 → XP_063118027.1  galactocerebrosidase isoform X2

    Related
    ENSRNOP00000102789.1, ENSRNOT00000138952.1

  12. XM_063261965.1 → XP_063118035.1  galactocerebrosidase isoform X3

RNA

  1. XR_010052097.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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