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Gulp1 GULP PTB domain containing engulfment adaptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314543, updated on 10-Oct-2024

Summary

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Official Symbol
Gulp1provided by RGD
Official Full Name
GULP PTB domain containing engulfment adaptor 1provided by RGD
Primary source
RGD:1306380
See related
EnsemblRapid:ENSRNOG00000003242 AllianceGenome:RGD:1306380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CED-6
Summary
Predicted to be involved in apoptotic process and lipid transport. Predicted to act upstream of or within phagocytosis, engulfment. Predicted to be located in cytoplasm. Orthologous to human GULP1 (GULP PTB domain containing engulfment adaptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 92.7), Lung (RPKM 85.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gulp1 in Genome Data Viewer
Location:
9q22
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (54114823..54391058)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (46622699..46899005)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (51263484..51538066)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene methyltransferase like 21C-like 1 Neighboring gene cell division cycle associated 3 like 1 Neighboring gene U6 spliceosomal RNA Neighboring gene heat shock protein family D (Hsp60) member 1, pseudogene 13 Neighboring gene adenosylhomocysteinase, pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A rat homologue of CED-6 is expressed in neurons and interacts with clathrin. Martins-Silva C, et al. Brain Res, 2006 Nov 13. PMID 17007823
  2. Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP). Su HP, et al. J Biol Chem, 2002 Apr 5. PMID 11729193
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The present findings suggest that CED-6 may have a role in endocytic trafficking or signaling in neurons.
    Title: A rat homologue of CED-6 is expressed in neurons and interacts with clathrin.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phagocytosis, engulfment IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phagocytosis, engulfment ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
PTB domain-containing engulfment adapter protein 1
Names
GULP, engulfment adaptor PTB domain containing 1
PTB domain adapter protein CED-6
cell death protein 6 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013171.2 → NP_001013189.1  PTB domain-containing engulfment adapter protein 1

    See identical proteins and their annotated locations for NP_001013189.1

    Status: VALIDATED

    Source sequence(s)
    BC087053, BM390519, CB738009
    UniProtKB/Swiss-Prot
    Q0PYK2, Q5PQS4
    UniProtKB/TrEMBL
    A0A0G2K2Q5, A6INS9
    Related
    ENSRNOP00000107499.1, ENSRNOT00000170737.1
    Conserved Domains (2) summary
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    cl40461
    Location:150 → 191
    ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    54114823..54391058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083451.2 → XP_038939379.1  PTB domain-containing engulfment adapter protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2Q5, A0A8L2Q1K4
    Conserved Domains (1) summary
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

  2. XM_063267053.1 → XP_063123123.1  PTB domain-containing engulfment adapter protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q0PYK2, Q5PQS4
    UniProtKB/TrEMBL
    A6INS9

  3. XM_039083457.2 → XP_038939385.1  PTB domain-containing engulfment adapter protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K2Q5
    Conserved Domains (1) summary
    cd01273
    Location:3 → 126
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

  4. XM_017596394.3 → XP_017451883.1  PTB domain-containing engulfment adapter protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2Q5, A0A8L2Q1K4
    Related
    ENSRNOP00000004463.5, ENSRNOT00000004463.10
    Conserved Domains (1) summary
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

  5. XM_039083454.2 → XP_038939382.1  PTB domain-containing engulfment adapter protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2Q5, A0A8L2Q1K4
    Conserved Domains (1) summary
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

  6. XM_063267052.1 → XP_063123122.1  PTB domain-containing engulfment adapter protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q0PYK2, Q5PQS4
    UniProtKB/TrEMBL
    A6INS9

  7. XM_017596393.3 → XP_017451882.1  PTB domain-containing engulfment adapter protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2Q5, A0A8L2Q1K4
    Conserved Domains (1) summary
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

  8. XM_039083452.2 → XP_038939380.1  PTB domain-containing engulfment adapter protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2Q5, A0A8L2Q1K4
    Conserved Domains (1) summary
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

  9. XM_039083455.2 → XP_038939383.1  PTB domain-containing engulfment adapter protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q0PYK2, Q5PQS4
    UniProtKB/TrEMBL
    A0A0G2K2Q5, A6INS9
    Conserved Domains (2) summary
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    cl40461
    Location:150 → 191
    ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

  10. XM_063267051.1 → XP_063123121.1  PTB domain-containing engulfment adapter protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q0PYK2, Q5PQS4
    UniProtKB/TrEMBL
    A6INS9

  11. XM_039083453.2 → XP_038939381.1  PTB domain-containing engulfment adapter protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2Q5, A0A8L2Q1K4
    Conserved Domains (1) summary
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

  12. XM_063267050.1 → XP_063123120.1  PTB domain-containing engulfment adapter protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8L2Q1K4

  13. XM_063267054.1 → XP_063123124.1  PTB domain-containing engulfment adapter protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q0PYK2, Q5PQS4
    UniProtKB/TrEMBL
    A6INS9

  14. XM_063267055.1 → XP_063123125.1  PTB domain-containing engulfment adapter protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q0PYK2, Q5PQS4
    UniProtKB/TrEMBL
    A6INS9
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PQS4.1 GenPept UniProtKB/Swiss-Prot:Q5PQS4

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