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Rasal3 RAS protein activator like 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314596, updated on 2-Nov-2024

Summary

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Official Symbol
Rasal3provided by RGD
Official Full Name
RAS protein activator like 3provided by RGD
Primary source
RGD:1309019
See related
EnsemblRapid:ENSRNOG00000006167 AllianceGenome:RGD:1309019
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309019
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in negative regulation of Ras protein signal transduction and positive regulation of NK T cell proliferation. Predicted to be located in cytoplasm and cytoplasmic side of membrane. Orthologous to human RASAL3 (RAS protein activator like 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 200.6), Spleen (RPKM 109.1) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rasal3 in Genome Data Viewer
Location:
7q11
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (12047090..12061883, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (11396554..11411347, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (14403592..14419570, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479821 Neighboring gene WIZ zinc finger Neighboring gene uncharacterized LOC134479820 Neighboring gene peptidoglycan recognition protein 2 Neighboring gene uncharacterized LOC134479822 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 39

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RASAL3, a novel hematopoietic RasGAP protein, regulates the number and functions of NKT cells. Saito S, et al. Eur J Immunol, 2015 May. PMID 25652366
  2. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337
  3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of NK T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RAS protein activator like-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134562.3 → NP_001128034.1  RAS protein activator like-3 isoform 2

    See identical proteins and their annotated locations for NP_001128034.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I5ZJL7, A6K948, D3ZWW3
    Related
    ENSRNOP00000059964.1, ENSRNOT00000066722.3
    Conserved Domains (5) summary
    cd05136
    Location:420 → 743
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    pfam12329
    Location:890 → 950
    TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
    cl14603
    Location:296 → 428
    C2; C2 domain
    cl17171
    Location:177 → 323
    PH-like; Pleckstrin homology-like domain
    cl19398
    Location:752 → 859
    Rep_3; Initiator Replication protein

  2. NM_001414936.1 → NP_001401865.1  RAS protein activator like-3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I6GE24
    Related
    ENSRNOP00000086442.1, ENSRNOT00000104813.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    12047090..12061883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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