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Rnf126 ring finger protein 126 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314613, updated on 11-Apr-2024

Summary

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Official Symbol
Rnf126provided by RGD
Official Full Name
ring finger protein 126provided by RGD
Primary source
RGD:1306011
See related
Ensembl:ENSRNOG00000009028 AllianceGenome:RGD:1306011
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable epidermal growth factor receptor binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular protein metabolic process; negative regulation of epidermal growth factor receptor signaling pathway; and retrograde transport, endosome to Golgi. Predicted to be located in cytosol and nucleoplasm. Orthologous to human RNF126 (ring finger protein 126). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 203.2), Brain (RPKM 71.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rnf126 in Genome Data Viewer
Location:
7q11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10590013..10597585)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9939359..9946963)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12820796..12828325)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene serine protease 57 Neighboring gene follistatin like 3 Neighboring gene fibroblast growth factor 22 Neighboring gene RNA polymerase mitochondrial

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. HSF1 phosphorylation by ERK/GSK3 suppresses RNF126 to sustain IGF-IIR expression for hypertension-induced cardiomyocyte hypertrophy. Huang CY, et al. J Cell Physiol, 2018 Feb. PMID 28383811
  2. The ubiquitin ligase RNF126 regulates the retrograde sorting of the cation-independent mannose 6-phosphate receptor. Smith CJ, et al. Exp Cell Res, 2014 Jan 15. PMID 24275455
  3. E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by targeting the tumor suppressor p21 for ubiquitin-mediated degradation. Zhi X, et al. Cancer Res, 2013 Jan 1. PMID 23026136
  4. The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor. Smith CJ, et al. J Cell Sci, 2013 Mar 15. PMID 23418353
  5. Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6. Rodrigo-Brenni MC, et al. Mol Cell, 2014 Jul 17. PMID 24981174, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Angiotensin II activates ERK/GSK3 to phosphorylate HSF1, resulting in RNF126 degradation, which stabilizes IGF-IIR protein expression and eventually results in cardiac hypertrophy.
    Title: HSF1 phosphorylation by ERK/GSK3 suppresses RNF126 to sustain IGF-IIR expression for hypertension-induced cardiomyocyte hypertrophy.
Submit: New GeneRIF Correction

General gene information

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Homology

Clone Names

  • MGC124770

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoplasm protein quality control by the ubiquitin-proteasome system ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K27-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K27-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K29-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K29-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF126
NP_001028874.1
XP_006240961.1
XP_017450300.1
XP_063119479.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033702.1 → NP_001028874.1  E3 ubiquitin-protein ligase RNF126

    See identical proteins and their annotated locations for NP_001028874.1

    Status: PROVISIONAL

    Source sequence(s)
    BC099810
    UniProtKB/TrEMBL
    A0A8I6GM09, F7ESD4, Q499Q1
    Related
    ENSRNOP00000012317.6, ENSRNOT00000012317.7
    Conserved Domains (2) summary
    pfam13639
    Location:245 → 287
    zf-RING_2; Ring finger domain
    pfam14369
    Location:10 → 40
    zinc_ribbon_9; zinc-ribbon

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    10590013..10597585
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594811.3 → XP_017450300.1  E3 ubiquitin-protein ligase RNF126 isoform X2

  2. XM_063263409.1 → XP_063119479.1  E3 ubiquitin-protein ligase RNF126 isoform X3

  3. XM_006240899.4 → XP_006240961.1  E3 ubiquitin-protein ligase RNF126 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GM09
    Conserved Domains (2) summary
    pfam13639
    Location:230 → 272
    zf-RING_2; Ring finger domain
    pfam14369
    Location:10 → 40
    zinc_ribbon_9; zinc-ribbon
Nucleotide Protein Strain
Heading Accession and Version

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