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Plppr3 phospholipid phosphatase related 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314614, updated on 17-Aug-2024

Summary

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Official Symbol
Plppr3provided by RGD
Official Full Name
phospholipid phosphatase related 3provided by RGD
Primary source
RGD:727823
See related
EnsemblRapid:ENSRNOG00000027940 AllianceGenome:RGD:727823
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lppr3; Prg-2
Summary
Predicted to enable lipid phosphatase activity and phosphatidate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation; phospholipid metabolic process; and signal transduction. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Orthologous to human PLPPR3 (phospholipid phosphatase related 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 57.8), Kidney (RPKM 11.0) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q11
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10481624..10493059)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9831162..9842434)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12652555..12663825)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene complement factor D Neighboring gene elastase, neutrophil expressed Neighboring gene proteinase 3 Neighboring gene polypyrimidine tract binding protein 1 Neighboring gene uncharacterized LOC134479815

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting. Bräuer AU, et al. Nat Neurosci, 2003 Jun. PMID 12730698
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phospholipid phosphatase-related protein type 3
Names
inactive phospholipid phosphatase PLPPR3
lipid phosphate phosphatase-related protein type 3
plasticity-related gene 2 protein
plasticity-related protein PRG-2
plasticity-related protein PRG-2-like
NP_853665.2
XP_063119480.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181634.3 → NP_853665.2  phospholipid phosphatase-related protein type 3

    See identical proteins and their annotated locations for NP_853665.2

    Status: VALIDATED

    Source sequence(s)
    BC167750, JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q7TMB0
    UniProtKB/TrEMBL
    B3DM92, F1LMM6
    Related
    ENSRNOP00000029601.4, ENSRNOT00000031315.8
    Conserved Domains (1) summary
    cd03384
    Location:127 → 276
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    10481624..10493059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263410.1 → XP_063119480.1  phospholipid phosphatase-related protein type 3 isoform X1

    UniProtKB/Swiss-Prot
    Q7TMB0
    UniProtKB/TrEMBL
    B3DM92, F1LMM6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TMB0.1 GenPept UniProtKB/Swiss-Prot:Q7TMB0

Gene LinkOut

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