Arhgap45 Rho GTPase activating protein 45 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arhgap45provided by RGD
Official Full Name: Rho GTPase activating protein 45provided by RGD
Primary source: RGD:1308662
See related: EnsemblRapid:ENSRNOG00000013220 AllianceGenome:RGD:1308662
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hmha1; RGD1308662
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of small GTPase mediated signal transduction. Predicted to be located in cytosol and plasma membrane. Predicted to be active in membrane. Orthologous to human ARHGAP45 (Rho GTPase activating protein 45). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 663.1), Spleen (RPKM 376.6) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (10325515..10340955, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (9674873..9690286, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (12541032..12741314, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D7Rat64 (e-PCR)
- UniSTS:119053

AU048460 (e-PCR)
- UniSTS:144910

RH139906 (e-PCR)
- UniSTS:221990

RH128461 (e-PCR)
- UniSTS:211769

RH133121 (e-PCR)
- UniSTS:216404

AW531576 (e-PCR)
- UniSTS:245123

Ptb (e-PCR), detects polymorphism
- UniSTS:144286

RH132727 (e-PCR)
- UniSTS:216010

RH94770 (e-PCR)
- UniSTS:120017

RH130951 (e-PCR)
- UniSTS:214235

RH128371 (e-PCR)
- UniSTS:211679

BE118278 (e-PCR)
- UniSTS:248804

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of small GTPase mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho GTPase-activating protein 45

Names: histocompatibility (minor) HA-1; minor histocompatibility protein HA-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108067.1 → NP_001101537.1 rho GTPase-activating protein 45

See identical proteins and their annotated locations for NP_001101537.1

Status: PROVISIONAL

Source sequence(s)

CH474029

UniProtKB/TrEMBL

A6K8T3, D4AAI2

Related

ENSRNOP00000101370.1, ENSRNOT00000134583.1

Conserved Domains (3) summary

cd20816
Location:698 → 748

C1_GMIP-like; protein kinase C conserved region 1 (C1 domain) found in the GEM-interacting protein (GMIP)-like family

cl02570
Location:756 → 966

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl12013
Location:278 → 529

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

10325515..10340955 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263414.1 → XP_063119484.1 rho GTPase-activating protein 45 isoform X3

Related

ENSRNOP00000057381.4, ENSRNOT00000060648.5
XM_039078979.2 → XP_038934907.1 rho GTPase-activating protein 45 isoform X2

UniProtKB/TrEMBL

D4AAI2

Conserved Domains (3) summary

cd20816
Location:646 → 696

C1_GMIP-like; protein kinase C conserved region 1 (C1 domain) found in the GEM-interacting protein (GMIP)-like family

cl02570
Location:704 → 914

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl12013
Location:291 → 366

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_039078978.2 → XP_038934906.1 rho GTPase-activating protein 45 isoform X1

UniProtKB/TrEMBL

A0A8I5ZKS6, D4AAI2

Related

ENSRNOP00000078406.1, ENSRNOT00000118662.2

Conserved Domains (3) summary

cd20816
Location:709 → 759

C1_GMIP-like; protein kinase C conserved region 1 (C1 domain) found in the GEM-interacting protein (GMIP)-like family

cl02570
Location:767 → 977

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl12013
Location:289 → 540

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_017594813.3 → XP_017450302.1 rho GTPase-activating protein 45 isoform X4

UniProtKB/TrEMBL

A0A8I5Y5N9, D4AAI2

Related

ENSRNOP00000076374.1, ENSRNOT00000115050.2
XM_039078980.2 → XP_038934908.1 rho GTPase-activating protein 45 isoform X5

Conserved Domains (2) summary

cd20816
Location:171 → 221

C1_GMIP-like; protein kinase C conserved region 1 (C1 domain) found in the GEM-interacting protein (GMIP)-like family

cl02570
Location:229 → 439

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...