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Tmprss9 transmembrane serine protease 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314636, updated on 2-Nov-2024

Summary

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Official Symbol
Tmprss9provided by RGD
Official Full Name
transmembrane serine protease 9provided by RGD
Primary source
RGD:1309581
See related
EnsemblRapid:ENSRNOG00000032429 AllianceGenome:RGD:1309581
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable serine-type peptidase activity. Predicted to act upstream of or within plasminogen activation. Predicted to be located in plasma membrane. Orthologous to human TMPRSS9 (transmembrane serine protease 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 9.8), Testes (RPKM 5.7) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmprss9 in Genome Data Viewer
Location:
7q11
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9460998..9481854, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8810321..8831177, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11678591..11710581, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479806 Neighboring gene lamin B2 Neighboring gene translocase of inner mitochondrial membrane 13 Neighboring gene uncharacterized LOC120093773 Neighboring gene signal peptide peptidase-like 2B Neighboring gene LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Serase-1B, a new splice variant of polyserase-1/TMPRSS9, activates urokinase-type plasminogen activator and the proteolytic activation is negatively regulated by glycosaminoglycans. Okumura Y, et al. Biochem J, 2006 Dec 15. PMID 16872279, Free PMC Article
  2. Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product. Cal S, et al. Proc Natl Acad Sci U S A, 2003 Aug 5. PMID 12886014, Free PMC Article
  3. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The isolation and characterization of serase-1B, a splice variant of polyserase-1, is reported.[Serase-1B]
    Title: Serase-1B, a new splice variant of polyserase-1/TMPRSS9, activates urokinase-type plasminogen activator and the proteolytic activation is negatively regulated by glycosaminoglycans.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within plasminogen activation ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protease serine 9
Names
polyserase-1
polyserase-I
polyserine protease 1
serase-1b
transmembrane protease, serine 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395516.1 → NP_001382445.1  transmembrane protease serine 9

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    P69526
    UniProtKB/TrEMBL
    A0A8L2QMN2
    Related
    ENSRNOP00000041782.4, ENSRNOT00000049221.7
    Conserved Domains (5) summary
    smart00020
    Location:238 → 467
    Tryp_SPc; Trypsin-like serine protease
    PHA03247
    Location:463 → 539
    PHA03247; large tegument protein UL36; Provisional
    cd00112
    Location:190 → 225
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:864 → 1089
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam01390
    Location:68 → 148
    SEA; SEA domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    9460998..9481854 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P69526.1 GenPept UniProtKB/Swiss-Prot:P69526

Gene LinkOut

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