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Dohh deoxyhypusine hydroxylase [ Rattus norvegicus (Norway rat) ]

Gene ID: 314644, updated on 18-Sep-2024

Summary

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Official Symbol
Dohhprovided by RGD
Official Full Name
deoxyhypusine hydroxylaseprovided by RGD
Primary source
RGD:1304783
See related
EnsemblRapid:ENSRNOG00000004259 AllianceGenome:RGD:1304783
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1304783
Summary
Predicted to enable deoxyhypusine monooxygenase activity and iron ion binding activity. Predicted to be involved in peptidyl-lysine modification to peptidyl-hypusine. Orthologous to human DOHH (deoxyhypusine hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 135.6), Brain (RPKM 106.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dohh in Genome Data Viewer
Location:
7q11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (8972202..8977025, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8321466..8326305, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11191127..11195971, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 24 Neighboring gene small integral membrane protein 44 Neighboring gene fizzy and cell division cycle 20 related 1 Neighboring gene tektin bundle interacting protein 1 Neighboring gene major facilitator superfamily domain containing 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Crystal Structure of the Peroxo-diiron(III) Intermediate of Deoxyhypusine Hydroxylase, an Oxygenase Involved in Hypusination. Han Z, et al. Structure, 2015 May 5. PMID 25865244
  2. Human deoxyhypusine hydroxylase, an enzyme involved in regulating cell growth, activates O2 with a nonheme diiron center. Vu VV, et al. Proc Natl Acad Sci U S A, 2009 Sep 1. PMID 19706422, Free PMC Article
  3. Deoxyhypusine hydroxylase is a Fe(II)-dependent, HEAT-repeat enzyme. Identification of amino acid residues critical for Fe(II) binding and catalysis [corrected]. Kim YS, et al. J Biol Chem, 2006 May 12. PMID 16533814, Free PMC Article
  4. A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation. Sievert H, et al. Dis Model Mech, 2014 Aug. PMID 24832488, Free PMC Article
  5. Specificity of the deoxyhypusine hydroxylase-eukaryotic translation initiation factor (eIF5A) interaction: identification of amino acid residues of the enzyme required for binding of its substrate, deoxyhypusine-containing eIF5A. Kang KR, et al. J Biol Chem, 2007 Mar 16. PMID 17213197, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables deoxyhypusine monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deoxyhypusine monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables deoxyhypusine monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables deoxyhypusine monooxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables iron ion binding ISO
Inferred from Sequence Orthology
more info
  
enables iron ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptidyl-lysine modification to peptidyl-hypusine IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within peptidyl-lysine modification to peptidyl-hypusine ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-lysine modification to peptidyl-hypusine ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-lysine modification to peptidyl-hypusine ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
deoxyhypusine hydroxylase
Names
deoxyhypusine dioxygenase
deoxyhypusine hydroxylase/monooxygenase
deoxyhypusine monooxygenase
NP_001020177.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025006.2 → NP_001020177.1  deoxyhypusine hydroxylase

    See identical proteins and their annotated locations for NP_001020177.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q5PPJ4
    UniProtKB/TrEMBL
    A0A8L2Q272
    Related
    ENSRNOP00000005640.5, ENSRNOT00000005640.8
    Conserved Domains (3) summary
    smart00567
    Location:52 → 80
    EZ_HEAT; E-Z type HEAT repeats
    pfam13646
    Location:7 → 96
    HEAT_2; HEAT repeats
    sd00044
    Location:39 → 67
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    8972202..8977025 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PPJ4.1 GenPept UniProtKB/Swiss-Prot:Q5PPJ4

Gene LinkOut

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