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Myo1f myosin IF [ Rattus norvegicus (Norway rat) ]

Gene ID: 314654, updated on 14-Nov-2024

Summary

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Official Symbol
Myo1fprovided by RGD
Official Full Name
myosin IFprovided by RGD
Primary source
RGD:1309750
See related
EnsemblRapid:ENSRNOG00000008409 AllianceGenome:RGD:1309750
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization and endocytosis. Predicted to act upstream of or within several processes, including defense response to Gram-positive bacterium; neutrophil degranulation; and positive regulation of neutrophil migration. Predicted to be located in cortical actin cytoskeleton and cytosol. Predicted to be part of filamentous actin. Predicted to be active in several cellular components, including actin cytoskeleton; microvillus; and plasma membrane. Orthologous to human MYO1F (myosin IF). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 216.4), Lung (RPKM 160.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Myo1f in Genome Data Viewer
Location:
7q11-q13
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (15065530..15116087)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (14363340..14413911)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (18440742..18491448)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549242 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif, 10 Neighboring gene uncharacterized LOC120093540 Neighboring gene BAF nuclear assembly factor 1, pseudogene 1 Neighboring gene zinc finger protein 414 Neighboring gene PML-RARA regulated adaptor molecule 1 Neighboring gene heterogeneous nuclear ribonucleoprotein M

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Modulation of cell adhesion and motility in the immune system by Myo1f. Kim SV, et al. Science, 2006 Oct 6. PMID 17023661
  2. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neutrophil degranulation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neutrophil mediated immunity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of neutrophil migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of neutrophil migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of filamentous actin ISO
Inferred from Sequence Orthology
more info
  
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
unconventional myosin-If
Names
myosin-If

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108076.2 → NP_001101546.1  unconventional myosin-If

    See identical proteins and their annotated locations for NP_001101546.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I6AWI1, A6KQG6, D4A7X9
    Related
    ENSRNOP00000011513.5, ENSRNOT00000011513.7
    Conserved Domains (4) summary
    cd11827
    Location:1045 → 1097
    SH3_MyoIe_If_like; Src homology 3 domain of Myosins Ie, If, and similar proteins
    smart00242
    Location:12 → 690
    MYSc; Myosin. Large ATPases
    cd01378
    Location:31 → 677
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:717 → 899
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    15065530..15116087
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079030.2 → XP_038934958.1  unconventional myosin-If isoform X1

    UniProtKB/TrEMBL
    A0A8I6AWI1
    Conserved Domains (4) summary
    cd11827
    Location:922 → 974
    SH3_MyoIe_If_like; Src homology 3 domain of Myosins Ie, If, and similar proteins
    PHA03247
    Location:797 → 920
    PHA03247; large tegument protein UL36; Provisional
    cd01378
    Location:1 → 554
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:594 → 792
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
Nucleotide Protein Strain
Heading Accession and Version

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