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Scyl2 SCY1 like pseudokinase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314717, updated on 2-Nov-2024

Summary

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Official Symbol
Scyl2provided by RGD
Official Full Name
SCY1 like pseudokinase 2provided by RGD
Primary source
RGD:1305665
See related
EnsemblRapid:ENSRNOG00000024955 AllianceGenome:RGD:1305665
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305665
Summary
Predicted to enable signaling receptor binding activity. Predicted to be involved in endosome to lysosome transport; pyramidal neuron development; and receptor-mediated endocytosis. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita-4. Orthologous to human SCYL2 (SCY1 like pseudokinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 162.6), Kidney (RPKM 155.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Scyl2 in Genome Data Viewer
Location:
7q13
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (25951734..26004663, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (24064404..24117338, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (30291087..30344464, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 1, group H, member 4 Neighboring gene Annexin A7, pseudogene 2 Neighboring gene solute carrier family 17 member 8 Neighboring gene uncharacterized LOC134479856 Neighboring gene uncharacterized LOC134479656

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5). Terabayashi T, et al. J Biol Chem, 2009 Sep 25. PMID 19643732, Free PMC Article
  2. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in brain development ISO
Inferred from Sequence Orthology
more info
  
involved_in clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in pyramidal neuron development ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SCY1-like protein 2
Names
SCY1-like 2
SCY1-like, kinase-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191780.1 → NP_001178709.1  SCY1-like protein 2

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A6IFR6, D4A1Y0
    Related
    ENSRNOP00000002638.5, ENSRNOT00000002638.9
    Conserved Domains (4) summary
    smart00220
    Location:32 → 327
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08430
    Location:742 → 874
    Forkhead_N; Forkhead N-terminal region
    cd14011
    Location:38 → 329
    PK_SCY1_like; Pseudokinase domain of Scy1-like proteins
    sd00044
    Location:373 → 403
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    25951734..26004663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006241242.5 → XP_006241304.1  SCY1-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AFM7, A6IFR6
    Conserved Domains (4) summary
    smart00220
    Location:32 → 327
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08430
    Location:745 → 877
    Forkhead_N; Forkhead N-terminal region
    cd14011
    Location:38 → 329
    PK_SCY1_like; Pseudokinase domain of Scy1-like proteins
    sd00044
    Location:373 → 403
    HEAT; HEAT repeat [structural motif]

  2. XM_006241241.5 → XP_006241303.1  SCY1-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JVC2, A6IFR6
    Related
    ENSRNOP00000069426.1, ENSRNOT00000082016.3
    Conserved Domains (4) summary
    smart00220
    Location:32 → 327
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08430
    Location:746 → 878
    Forkhead_N; Forkhead N-terminal region
    cd14011
    Location:38 → 329
    PK_SCY1_like; Pseudokinase domain of Scy1-like proteins
    sd00044
    Location:373 → 403
    HEAT; HEAT repeat [structural motif]

  3. XM_017594827.3 → XP_017450316.1  SCY1-like protein 2 isoform X3

    UniProtKB/TrEMBL
    A6IFR6
    Related
    ENSRNOP00000091677.2, ENSRNOT00000119175.2

  4. XM_063263439.1 → XP_063119509.1  SCY1-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JVC2
Nucleotide Protein Strain
Heading Accession and Version

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