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Card10 caspase recruitment domain family, member 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315120, updated on 15-Nov-2024

Summary

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Official Symbol
Card10provided by RGD
Official Full Name
caspase recruitment domain family, member 10provided by RGD
Primary source
RGD:1304949
See related
EnsemblRapid:ENSRNOG00000008401 AllianceGenome:RGD:1304949
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in several processes, including activation of NF-kappaB-inducing kinase activity; negative regulation of cell migration involved in sprouting angiogenesis; and positive regulation of canonical NF-kappaB signal transduction. Predicted to be active in immunological synapse. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human CARD10 (caspase recruitment domain family member 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 106.0), Lung (RPKM 64.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Card10 in Genome Data Viewer
Location:
7q34
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112210944..112252044, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (110330460..110371551, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (119998639..120028632, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549375 Neighboring gene extracellular leucine-rich repeat and fibronectin type III domain containing 2 Neighboring gene MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene CDC42 effector protein 1 Neighboring gene uncharacterized LOC134479608 Neighboring gene galectin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Lipopolysaccharide-induced microRNA-146a targets CARD10 and regulates angiogenesis in human umbilical vein endothelial cells. Rau CS, et al. Toxicol Sci, 2014 Aug 1. PMID 24863965
  2. Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B. Wang L, et al. J Biol Chem, 2001 Jun 15. PMID 11259443
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in activation of NF-kappaB-inducing kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in immunological synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
caspase recruitment domain-containing protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130554.1 → NP_001124026.1  caspase recruitment domain-containing protein 10 isoform 1

    See identical proteins and their annotated locations for NP_001124026.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473950
    UniProtKB/TrEMBL
    A6HSM0, D4A425
    Conserved Domains (3) summary
    COG1196
    Location:147 → 450
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd08807
    Location:27 → 112
    CARD_CARD10_CARMA3; Caspase activation and recruitment domain of CARD10-like proteins
    cl17036
    Location:696 → 761
    SH3; Src Homology 3 domain superfamily

  2. NM_001434610.1 → NP_001421539.1  caspase recruitment domain-containing protein 10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007

  3. NM_001434611.1 → NP_001421540.1  caspase recruitment domain-containing protein 10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    112210944..112252044 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079260.2 → XP_038935188.1  caspase recruitment domain-containing protein 10 isoform X4

    UniProtKB/TrEMBL
    D4A425
    Conserved Domains (3) summary
    COG1196
    Location:147 → 450
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd08807
    Location:27 → 112
    CARD_CARD10_CARMA3; Caspase activation and recruitment domain of CARD10-like proteins
    cl17036
    Location:735 → 800
    SH3; Src Homology 3 domain superfamily

  2. XM_063263609.1 → XP_063119679.1  caspase recruitment domain-containing protein 10 isoform X4

  3. XM_063263610.1 → XP_063119680.1  caspase recruitment domain-containing protein 10 isoform X4

  4. XM_039079258.2 → XP_038935186.1  caspase recruitment domain-containing protein 10 isoform X2

    UniProtKB/TrEMBL
    D4A425
    Conserved Domains (3) summary
    COG1196
    Location:196 → 499
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd08807
    Location:76 → 161
    CARD_CARD10_CARMA3; Caspase activation and recruitment domain of CARD10-like proteins
    cl17036
    Location:784 → 849
    SH3; Src Homology 3 domain superfamily

  5. XM_039079257.2 → XP_038935185.1  caspase recruitment domain-containing protein 10 isoform X1

    UniProtKB/TrEMBL
    D4A425
    Conserved Domains (3) summary
    COG1196
    Location:196 → 499
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd08807
    Location:76 → 161
    CARD_CARD10_CARMA3; Caspase activation and recruitment domain of CARD10-like proteins
    cl17036
    Location:784 → 849
    SH3; Src Homology 3 domain superfamily

  6. XM_063263608.1 → XP_063119678.1  caspase recruitment domain-containing protein 10 isoform X3

    Related
    ENSRNOP00000011215.6, ENSRNOT00000011215.8

  7. XM_039079261.2 → XP_038935189.1  caspase recruitment domain-containing protein 10 isoform X5

    Conserved Domains (2) summary
    COG1196
    Location:196 → 499
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd08807
    Location:76 → 161
    CARD_CARD10_CARMA3; Caspase activation and recruitment domain of CARD10-like proteins
Nucleotide Protein Strain
Heading Accession and Version

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