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Ddx17 DEAD-box helicase 17 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315133, updated on 17-Aug-2024

Summary

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Official Symbol
Ddx17provided by RGD
Official Full Name
DEAD-box helicase 17provided by RGD
Primary source
RGD:1304945
See related
EnsemblRapid:ENSRNOG00000051170 AllianceGenome:RGD:1304945
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA helicase activity; long noncoding RNA binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including RNA metabolic process; intracellular steroid hormone receptor signaling pathway; and regulation of RNA metabolic process. Predicted to be located in nuclear speck. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleus. Orthologous to human DDX17 (DEAD-box helicase 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 1158.2), Lung (RPKM 966.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ddx17 in Genome Data Viewer
Location:
7q34
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112971522..112989747, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (111091127..111109353, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120761843..120765012, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 4 Neighboring gene KDEL endoplasmic reticulum protein retention receptor 3 Neighboring gene DNA meiotic recombinase 1 Neighboring gene family with sequence similarity 227, member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The Ddx5 and Ddx17 RNA helicases are cornerstones in the complex regulatory array of steroid hormone-signaling pathways. Samaan S, et al. Nucleic Acids Res, 2014 Feb. PMID 24275493, Free PMC Article
  2. Myogenin promoter-associated lncRNA Myoparr is essential for myogenic differentiation. Hitachi K, et al. EMBO Rep, 2019 Mar. PMID 30622218, Free PMC Article
  3. The miRNA biogenesis factors, p72/DDX17 and KHSRP regulate the protein level of Ago2 in human cells. Connerty P, et al. Biochim Biophys Acta, 2016 Oct. PMID 27478153
  4. Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF. Shin S, et al. J Cell Biochem, 2007 Aug 1. PMID 17226766
  5. RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation. Dardenne E, et al. Cell Rep, 2014 Jun 26. PMID 24910439

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC109323

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables lncRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonucleoprotein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
  
involved_in estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in miRNA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in miRNA transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in myoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of skeletal muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable ATP-dependent RNA helicase DDX17
Names
DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
NP_001015018.1
NP_001359065.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001015018.2 → NP_001015018.1  probable ATP-dependent RNA helicase DDX17 isoform 2

    See identical proteins and their annotated locations for NP_001015018.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks most of the exons in the coding region, compared to transcript variant 1. The resulting protein (isoform 2) is much shorter with a different N-terminus when compared to isoform 1.
    Source sequence(s)
    FQ236955, JAXUCZ010000007
    UniProtKB/TrEMBL
    A6HSS5, Q568Z8
    Conserved Domains (1) summary
    PTZ00110
    Location:22 → 118
    PTZ00110; helicase; Provisional

  2. NM_001372136.1 → NP_001359065.1  probable ATP-dependent RNA helicase DDX17 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    FQ236955, JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A096MIX2, A6HSS3, E9PT29
    Related
    ENSRNOP00000018185.8, ENSRNOT00000018185.9
    Conserved Domains (1) summary
    PTZ00110
    Location:32 → 502
    PTZ00110; helicase; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    112971522..112989747 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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