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Poldip3 DNA polymerase delta interacting protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315170, updated on 2-Nov-2024

Summary

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Official Symbol
Poldip3provided by RGD
Official Full Name
DNA polymerase delta interacting protein 3provided by RGD
Primary source
RGD:1311073
See related
EnsemblRapid:ENSRNOG00000022877 AllianceGenome:RGD:1311073
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus and positive regulation of translation. Predicted to be located in cytoplasmic ribonucleoprotein granule. Predicted to be active in nuclear speck. Orthologous to human POLDIP3 (DNA polymerase delta interacting protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 271.0), Spleen (RPKM 255.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Poldip3 in Genome Data Viewer
Location:
7q34
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (116154892..116183319, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (114274845..114303278, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (123992167..124020596, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692952 Neighboring gene serine hydrolase-like 2 Neighboring gene ribosomal RNA processing 7 homolog A Neighboring gene transfer RNA proline (anticodon AGG) 38 Neighboring gene RNA, U12 small nuclear

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. SKAR is a specific target of S6 kinase 1 in cell growth control. Richardson CJ, et al. Curr Biol, 2004 Sep 7. PMID 15341740
  2. The proteins PDIP3 and ZC11A associate with the human TREX complex in an ATP-dependent manner and function in mRNA export. Folco EG, et al. PLoS One, 2012. PMID 22928037, Free PMC Article
  3. ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complex. Dufu K, et al. Genes Dev, 2010 Sep 15. PMID 20844015, Free PMC Article
  4. SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs. Ma XM, et al. Cell, 2008 Apr 18. PMID 18423201
  5. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in poly(A)+ mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasmic ribonucleoprotein granule IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
polymerase delta-interacting protein 3
Names
polymerase (DNA) delta interacting protein 3
polymerase (DNA-directed), delta interacting protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130506.1 → NP_001123978.1  polymerase delta-interacting protein 3

    See identical proteins and their annotated locations for NP_001123978.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473950
    UniProtKB/TrEMBL
    A0A0G2JXM5, A6HT84
    Related
    ENSRNOP00000070332.3, ENSRNOT00000082524.3
    Conserved Domains (2) summary
    COG0724
    Location:216 → 406
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12681
    Location:280 → 348
    RRM_SKAR; RNA recognition motif in S6K1 Aly/REF-like target (SKAR) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    116154892..116183319 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242090.3 → XP_006242152.1  polymerase delta-interacting protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006242152.1

    UniProtKB/TrEMBL
    A0A0G2JXM5, A6HT83, D4A2B0
    Related
    ENSRNOP00000052842.3, ENSRNOT00000055988.5
    Conserved Domains (2) summary
    COG0724
    Location:187 → 377
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12681
    Location:251 → 319
    RRM_SKAR; RNA recognition motif in S6K1 Aly/REF-like target (SKAR) and similar proteins

  2. XM_063263621.1 → XP_063119691.1  polymerase delta-interacting protein 3 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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