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Mcat malonyl-CoA-acyl carrier protein transacylase [ Rattus norvegicus (Norway rat) ]

Gene ID: 315173, updated on 10-Jul-2024

Summary

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Official Symbol
Mcatprovided by RGD
Official Full Name
malonyl-CoA-acyl carrier protein transacylaseprovided by RGD
Primary source
RGD:1306698
See related
EnsemblRapid:ENSRNOG00000010539 AllianceGenome:RGD:1306698
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306698
Summary
Predicted to enable [acyl-carrier-protein] S-malonyltransferase activity. Predicted to be involved in fatty acid biosynthetic process. Predicted to be active in mitochondrion. Orthologous to human MCAT (malonyl-CoA-acyl carrier protein transacylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 169.0), Adrenal (RPKM 92.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mcat in Genome Data Viewer
Location:
7q34
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (116573632..116585767, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (114693612..114705677, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (124412762..124424966, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene TTL family tubulin polyglutamylase complex subunit L1 Neighboring gene BCL2-interacting killer Neighboring gene uncharacterized LOC134479952 Neighboring gene uncharacterized LOC134479950 Neighboring gene translocator protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning, expression, characterization, and interaction of two components of a human mitochondrial fatty acid synthase. Malonyltransferase and acyl carrier protein. Zhang L, et al. J Biol Chem, 2003 Oct 10. PMID 12882974
  2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables [acyl-carrier-protein] S-malonyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [acyl-carrier-protein] S-malonyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial small ribosomal subunit assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
malonyl-CoA-acyl carrier protein transacylase, mitochondrial
Names
malonyl CoA:ACP acyltransferase (mitochondrial)
NP_001178717.1
XP_006242153.1
XP_063119692.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191788.1 → NP_001178717.1  malonyl-CoA-acyl carrier protein transacylase, mitochondrial

    See identical proteins and their annotated locations for NP_001178717.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    D3ZPF2
    Related
    ENSRNOP00000013994.5, ENSRNOT00000013994.7
    Conserved Domains (1) summary
    cl08282
    Location:63 → 356
    Acyl_transf_1; Acyl transferase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    116573632..116585767 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242091.2 → XP_006242153.1  malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006242153.1

    UniProtKB/TrEMBL
    D3ZPF2
    Conserved Domains (1) summary
    cl08282
    Location:63 → 356
    Acyl_transf_1; Acyl transferase domain

  2. XM_063263622.1 → XP_063119692.1  malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A6HT99
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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