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Twf1 twinfilin actin-binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315265, updated on 2-Nov-2024

Summary

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Official Symbol
Twf1provided by RGD
Official Full Name
twinfilin actin-binding protein 1provided by RGD
Primary source
RGD:1311872
See related
EnsemblRapid:ENSRNOG00000022507 AllianceGenome:RGD:1311872
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ptk9
Summary
Predicted to enable actin binding activity; anion binding activity; and protein tyrosine kinase activity. Predicted to be involved in several processes, including actin filament depolymerization; negative regulation of actin filament polymerization; and regulation of plasma membrane bounded cell projection organization. Predicted to be located in several cellular components, including filopodium; perinuclear region of cytoplasm; and ruffle membrane. Predicted to be active in actin filament and myofibril. Orthologous to human TWF1 (twinfilin actin binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 527.0), Adrenal (RPKM 270.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Twf1 in Genome Data Viewer
Location:
7q35
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (127595210..127607821, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (125715938..125727834, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (135838647..135850542, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351537 Neighboring gene ribosomal protein L18, pseudogene 11 Neighboring gene pseudouridine synthase 7 like Neighboring gene interleukin-1 receptor-associated kinase 4 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4, pseudogene 1 Neighboring gene transmembrane protein 117 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Alteration of twinfilin1 expression underlies opioid withdrawal-induced remodeling of actin cytoskeleton at synapses and formation of aversive memory. Wang YJ, et al. Mol Psychiatry, 2021 Nov. PMID 33963280
  2. Mouse A6/twinfilin is an actin monomer-binding protein that localizes to the regions of rapid actin dynamics. Vartiainen M, et al. Mol Cell Biol, 2000 Mar. PMID 10669753, Free PMC Article
  3. Cloning and characterization of the mouse homolog of the human A6 gene. Beeler JF, et al. Gene, 1997 Jul 1. PMID 9249064
  4. Attenuation of microRNA-1 derepresses the cytoskeleton regulatory protein twinfilin-1 to provoke cardiac hypertrophy. Li Q, et al. J Cell Sci, 2010 Jul 15. PMID 20571053
  5. A recurrent de novo mutation in ACTG1 causes isolated ocular coloboma. Rainger J, et al. Hum Mutat, 2017 Aug. PMID 28493397, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Alteration of twinfilin1 expression underlies opioid withdrawal-induced remodeling of actin cytoskeleton at synapses and formation of aversive memory.
    Title: Alteration of twinfilin1 expression underlies opioid withdrawal-induced remodeling of actin cytoskeleton at synapses and formation of aversive memory.
  2. like Twf1, mouse Twf2 is a filament barbed-end capping protein, and that two tissue-specific and biochemically distinct isoforms are generated from the Twf2 gene through alternative promoter usage
    Title: Two biochemically distinct and tissue-specific twinfilin isoforms are generated from the mouse Twf2 gene by alternative promoter usage.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC105817

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables actin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin monomer binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin monomer binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
NOT enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin filament depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in barbed-end actin filament capping ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sequestering of actin monomers IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sequestering of actin monomers ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in filopodium ISO
Inferred from Sequence Orthology
more info
  
is_active_in myofibril IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in myofibril ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
twinfilin-1
Names
protein tyrosine kinase 9
twinfilin, actin-binding protein, homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008521.2 → NP_001008521.1  twinfilin-1

    See identical proteins and their annotated locations for NP_001008521.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q5RJR2
    UniProtKB/TrEMBL
    A0A8L2QHU7, A6K7V2
    Related
    ENSRNOP00000106097.1, ENSRNOT00000145237.1
    Conserved Domains (2) summary
    cd11284
    Location:176 → 311
    ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
    cd11285
    Location:4 → 142
    ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    127595210..127607821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263657.1 → XP_063119727.1  twinfilin-1 isoform X2

  2. XM_063263656.1 → XP_063119726.1  twinfilin-1 isoform X1

    Related
    ENSRNOP00000101868.1, ENSRNOT00000173146.1

  3. XM_063263659.1 → XP_063119729.1  twinfilin-1 isoform X4

  4. XM_063263658.1 → XP_063119728.1  twinfilin-1 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5RJR2.1 GenPept UniProtKB/Swiss-Prot:Q5RJR2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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Tools
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