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Ano6 anoctamin 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315272, updated on 2-Nov-2024

Summary

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Official Symbol
Ano6provided by RGD
Official Full Name
anoctamin 6provided by RGD
Primary source
RGD:1304765
See related
EnsemblRapid:ENSRNOG00000006995 AllianceGenome:RGD:1304765
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tmem16f
Summary
Predicted to enable monoatomic ion channel activity; phospholipid scramblase activity; and protein homodimerization activity. Involved in positive regulation of potassium ion export across plasma membrane. Predicted to be located in cytosol. Predicted to be part of chloride channel complex. Predicted to be active in cholinergic synapse and synaptic membrane. Human ortholog(s) of this gene implicated in Scott syndrome; ankylosing spondylitis; and inflammatory bowel disease. Orthologous to human ANO6 (anoctamin 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 201.5), Lung (RPKM 183.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ano6 in Genome Data Viewer
Location:
7q35
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (128812842..128992805)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (126933919..127113588)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (137142063..137335208)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene developing brain homeobox 2 Neighboring gene uncharacterized LOC102547300 Neighboring gene uncharacterized LOC134479558 Neighboring gene histone deacetylase 1-like Neighboring gene uncharacterized LOC102549406 Neighboring gene uncharacterized LOC102549313

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TMEM16F Aggravates Neuronal Loss by Mediating Microglial Phagocytosis of Neurons in a Rat Experimental Cerebral Ischemia and Reperfusion Model. Zhang Y, et al. Front Immunol, 2020. PMID 32733436, Free PMC Article
  2. Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F. Alvadia C, et al. Elife, 2019 Feb 20. PMID 30785399, Free PMC Article
  3. Calcium-dependent phospholipid scrambling by TMEM16F. Suzuki J, et al. Nature, 2010 Dec 9. PMID 21107324
  4. Association study of polymorphisms rs4552569 and rs17095830 and the risk of ankylosing spondylitis in a Taiwanese population. Wei JC, et al. PLoS One, 2013. PMID 23308121, Free PMC Article
  5. TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation. Yang H, et al. Cell, 2012 Sep 28. PMID 23021219, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TMEM16F Aggravates Neuronal Loss by Mediating Microglial Phagocytosis of Neurons in a Rat Experimental Cerebral Ischemia and Reperfusion Model.
    Title: TMEM16F Aggravates Neuronal Loss by Mediating Microglial Phagocytosis of Neurons in a Rat Experimental Cerebral Ischemia and Reperfusion Model.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium-activated cation channel activity ISO
Inferred from Sequence Orthology
more info
  
enables chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
NOT enables intracellularly calcium-gated chloride channel activity ISO
Inferred from Sequence Orthology
more info
  
enables intracellularly calcium-gated chloride channel activity ISO
Inferred from Sequence Orthology
more info
  
enables phospholipid scramblase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated chloride channel activity ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated monoatomic ion channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of blood coagulation via clotting cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in bleb assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in blood coagulation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within bone mineralization involved in bone maturation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within calcium activated galactosylceramide scrambling ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium activated phosphatidylcholine scrambling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within calcium activated phosphatidylcholine scrambling ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium activated phosphatidylserine scrambling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within calcium activated phosphatidylserine scrambling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within calcium activated phospholipid scrambling ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chloride transport ISO
Inferred from Sequence Orthology
more info
  
involved_in chloride transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within dendritic cell chemotaxis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment of localization in cell ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell volume ISO
Inferred from Sequence Orthology
more info
  
NOT acts_upstream_of_or_within phosphatidylserine exposure on apoptotic cell surface ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylserine exposure on blood platelet ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid translocation ISO
Inferred from Sequence Orthology
more info
  
involved_in plasma membrane phospholipid scrambling ISO
Inferred from Sequence Orthology
more info
  
involved_in pore complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of monoatomic ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phagocytosis, engulfment ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of potassium ion export across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in purinergic nucleotide receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chloride channel complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cholinergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
anoctamin-6
Names
transmembrane protein 16F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401001.1 → NP_001387930.1  anoctamin-6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I5ZRU7
    Related
    ENSRNOP00000092185.1, ENSRNOT00000100449.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    128812842..128992805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008765735.4 → XP_008763957.1  anoctamin-6 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AA94, A0A8I6G530
    Related
    ENSRNOP00000089627.1, ENSRNOT00000098138.2
    Conserved Domains (2) summary
    pfam04547
    Location:309 → 893
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:84 → 306
    Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin

  2. XM_039079320.2 → XP_038935248.1  anoctamin-6 isoform X4

    UniProtKB/TrEMBL
    A0A0G2K1M7, A0A8I6G530
    Conserved Domains (2) summary
    pfam04547
    Location:286 → 869
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:61 → 283
    Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

  3. XM_039079322.2 → XP_038935250.1  anoctamin-6 isoform X5

    UniProtKB/TrEMBL
    A0A8I6ASC3, A0A8I6G530
    Conserved Domains (2) summary
    pfam04547
    Location:265 → 848
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:40 → 262
    Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

  4. XM_039079319.2 → XP_038935247.1  anoctamin-6 isoform X3

    UniProtKB/TrEMBL
    A0A8I6G530
    Conserved Domains (2) summary
    pfam04547
    Location:294 → 877
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:69 → 291
    Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

  5. XM_039079318.2 → XP_038935246.1  anoctamin-6 isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y1S2, A0A8I6G530
    Related
    ENSRNOP00000077951.1, ENSRNOT00000110510.2
    Conserved Domains (2) summary
    pfam04547
    Location:301 → 884
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:76 → 298
    Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108108.1: Suppressed sequence

    Description
    NM_001108108.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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