Panx1 Pannexin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Panx1provided by RGD
Official Full Name: Pannexin 1provided by RGD
Primary source: RGD:735204
See related: EnsemblRapid:ENSRNOG00000010060 AllianceGenome:RGD:735204
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: px1
Summary: The protein encoded by this gene is a plasma membrane protein that is a structural component of gap junctions. The encoded protein acts as a homodimer or as a heterodimer with other isoforms or proteins. Two additional variants have been found, and the isoforms expressed from them are found in the cytoplasm. It is thought that these two isoforms could attenuate the actions of the membrane-bound protein. [provided by RefSeq, Jul 2012]
Expression: Biased expression in Brain (RPKM 30.6), Thymus (RPKM 24.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (20128783..20171200, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (11851176..11889774, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (13567185..13606040, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Age-Dependent Activation of Pannexin1 Function Contributes to the Development of Epileptogenesis in Autosomal Dominant Sleep-related Hypermotor Epilepsy Model Rats.
Title: Age-Dependent Activation of Pannexin1 Function Contributes to the Development of Epileptogenesis in Autosomal Dominant Sleep-related Hypermotor Epilepsy Model Rats.
Pannexin 1 role in the trigeminal ganglion in infraorbital nerve injury-induced mechanical allodynia.
Title: Pannexin 1 role in the trigeminal ganglion in infraorbital nerve injury-induced mechanical allodynia.
Sex-specific effects of metformin and liraglutide on renal pathology and expression of connexin 45 and pannexin 1 following long-term high-fat high-sugar diet.
Title: Sex-specific effects of metformin and liraglutide on renal pathology and expression of connexin 45 and pannexin 1 following long-term high-fat high-sugar diet.
Pannexin 1-Mediated ATP Signaling in the Trigeminal Spinal Subnucleus Caudalis Is Involved in Tongue Cancer Pain.
Title: Pannexin 1-Mediated ATP Signaling in the Trigeminal Spinal Subnucleus Caudalis Is Involved in Tongue Cancer Pain.
A physiologic rise in cytoplasmic calcium ion signal increases pannexin1 channel activity via a C-terminus phosphorylation by CaMKII.
Title: A physiologic rise in cytoplasmic calcium ion signal increases pannexin1 channel activity via a C-terminus phosphorylation by CaMKII.
Role of Pannexin 1 ATP-Permeable Channels in the Regulation of Signaling Pathways during Skeletal Muscle Unloading.
Title: Role of Pannexin 1 ATP-Permeable Channels in the Regulation of Signaling Pathways during Skeletal Muscle Unloading.
Mutational effects of Pannexin 1 R217H depend on the carboxyl-terminus.
Title: Mutational effects of Pannexin 1 R217H depend on the carboxyl-terminus.
Cystic fibrosis transmembrane conductance regulator-dependent bicarbonate entry controls rat cardiomyocyte ATP release via pannexin1 through mitochondrial signalling and caspase activation.
Title: Cystic fibrosis transmembrane conductance regulator-dependent bicarbonate entry controls rat cardiomyocyte ATP release via pannexin1 through mitochondrial signalling and caspase activation.
Functional Coupling between the P2X7 Receptor and Pannexin-1 Channel in Rat Trigeminal Ganglion Neurons.
Title: Functional Coupling between the P2X(7) Receptor and Pannexin-1 Channel in Rat Trigeminal Ganglion Neurons.
Novel Pannexin-1-Coupled Signaling Cascade Involved in the Control of Endothelial Cell Function and NO-Dependent Relaxation.
Title: Novel Pannexin-1-Coupled Signaling Cascade Involved in the Control of Endothelial Cell Function and NO-Dependent Relaxation.

Submit: New GeneRIF Correction See all GeneRIFs (52)

General gene information

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Markers

AI232305 (e-PCR)
- UniSTS:250072

RH138823 (e-PCR)
- UniSTS:220910

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables ATP transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables calcium channel activity	ISO Inferred from Sequence Orthology more info
enables calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables channel activity	IEA Inferred from Electronic Annotation more info
enables gap junction channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
NOT enables gap junction hemi-channel activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables leak channel activity	ISO Inferred from Sequence Orthology more info
enables leak channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables monoatomic anion channel activity	ISO Inferred from Sequence Orthology more info
enables monoatomic anion channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables structural molecule activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables wide pore channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ATP transport	ISO Inferred from Sequence Orthology more info
involved_in ATP transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic anion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic anion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in monoatomic cation transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic cation transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-1 alpha production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of macrophage cytokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to ATP	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to ischemia	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in bleb	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in gap junction	ISO Inferred from Sequence Orthology more info
located_in gap junction	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: pannexin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270548.1 → NP_001257477.1 pannexin-1 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate splice junction at the 3' end of an exon and lacks the following alternate exon compared to variant 1. The resulting isoform (c) has a short alternate aa sequence in place of a larger segment compared to isoform a.

Source sequence(s)

BM385439, GQ499839, GQ499840, JAXUCZ010000008

UniProtKB/TrEMBL

A0A0G2KA39, E0X642

Related

ENSRNOP00000075246.1, ENSRNOT00000083395.3
NM_001270549.1 → NP_001257478.1 pannexin-1 isoform d

See identical proteins and their annotated locations for NP_001257478.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate splice junction at the 3' end of an exon compared to variant 1, that causes a frameshift. The resulting isoform (d) has a shorter and distinct C-terminus compared to isoform a.

Source sequence(s)

BM385439, GQ499839, GQ499840, JAXUCZ010000008

UniProtKB/TrEMBL

E0X643
NM_199397.2 → NP_955429.1 pannexin-1 isoform a

See identical proteins and their annotated locations for NP_955429.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

BM385439, JAXUCZ010000008

UniProtKB/Swiss-Prot

P60570

UniProtKB/TrEMBL

A6JNB1, E0X642

Related

ENSRNOP00000013577.3, ENSRNOT00000013577.7