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Eepd1 endonuclease/exonuclease/phosphatase family domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315500, updated on 2-Nov-2024

Summary

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Official Symbol
Eepd1provided by RGD
Official Full Name
endonuclease/exonuclease/phosphatase family domain containing 1provided by RGD
Primary source
RGD:1307401
See related
EnsemblRapid:ENSRNOG00000006931 AllianceGenome:RGD:1307401
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307401
Summary
Predicted to enable DNA binding activity and catalytic activity. Predicted to be involved in positive regulation of cholesterol efflux. Predicted to be active in plasma membrane. Orthologous to human EEPD1 (endonuclease/exonuclease/phosphatase family domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 1223.6), Muscle (RPKM 336.2) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Eepd1 in Genome Data Viewer
Location:
8q13
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (32233834..32340148)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (23957258..24064343)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (26651241..26758330)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351664 Neighboring gene septin 7 Neighboring gene ribosomal protein S6, pseudogene 5 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC108351840 Neighboring gene uncharacterized LOC134479971

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux. Nelson JK, et al. Arterioscler Thromb Vasc Biol, 2017 Mar. PMID 28082258, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC116390

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
endonuclease/exonuclease/phosphatase family domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014088.4 → NP_001014110.1  endonuclease/exonuclease/phosphatase family domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001014110.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q5XI74
    UniProtKB/TrEMBL
    A6JYC0
    Related
    ENSRNOP00000009342.5, ENSRNOT00000009342.7
    Conserved Domains (3) summary
    cd10283
    Location:261 → 538
    MnuA_DNase1-like; Mycoplasma pulmonis MnuA nuclease-like
    COG1555
    Location:43 → 195
    ComEA; DNA uptake protein ComE and related DNA-binding proteins [Replication, recombination and repair]
    pfam12836
    Location:37 → 95
    HHH_3; Helix-hairpin-helix motif

  2. NM_001429804.1 → NP_001416733.1  endonuclease/exonuclease/phosphatase family domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I5ZPH9

RNA

  1. NR_190792.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  2. NR_190793.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  3. NR_190794.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    32233834..32340148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242727.5 → XP_006242789.1  endonuclease/exonuclease/phosphatase family domain-containing protein 1 isoform X1

    Related
    ENSRNOP00000079888.1, ENSRNOT00000118856.2
    Conserved Domains (3) summary
    cd10283
    Location:261 → 501
    MnuA_DNase1-like; Mycoplasma pulmonis MnuA nuclease-like
    COG1555
    Location:43 → 195
    ComEA; DNA uptake protein ComE and related DNA-binding proteins [Replication, recombination and repair]
    pfam12836
    Location:37 → 95
    HHH_3; Helix-hairpin-helix motif

  2. XM_063265374.1 → XP_063121444.1  endonuclease/exonuclease/phosphatase family domain-containing protein 1 isoform X2

RNA

  1. XR_010053959.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XI74.1 GenPept UniProtKB/Swiss-Prot:Q5XI74

Gene LinkOut

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Chemical Information
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