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Nfrkb nuclear factor related to kappa B binding protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 315523, updated on 10-Jul-2024

Summary

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Official Symbol
Nfrkbprovided by RGD
Official Full Name
nuclear factor related to kappa B binding proteinprovided by RGD
Primary source
RGD:1310558
See related
EnsemblRapid:ENSRNOG00000008278 AllianceGenome:RGD:1310558
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protease binding activity. Predicted to be located in nucleoplasm. Predicted to be part of Ino80 complex. Orthologous to human NFRKB (nuclear factor related to kappaB binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 132.8), Spleen (RPKM 99.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nfrkb in Genome Data Viewer
Location:
8q13
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (38089574..38121506)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (29831802..29863360)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (32530412..32561955)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene NOP16 nucleolar protein, pseudogene 1 Neighboring gene PR/SET domain 10 Neighboring gene ribosomal protein L32 like 1 Neighboring gene transmembrane protein 45b Neighboring gene uncharacterized LOC134480011 Neighboring gene large ribosomal subunit protein eL21-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. Chen L, et al. J Biol Chem, 2011 Apr 1. PMID 21303910, Free PMC Article
  2. The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics. Watanabe S, et al. Cold Spring Harb Symp Quant Biol, 2010. PMID 21502417
  3. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. Yao T, et al. Mol Cell, 2008 Sep 26. PMID 18922472, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protease binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomere maintenance in response to DNA damage ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA strand elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chromosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Ino80 complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nuclear factor related to kappa-B-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108133.1 → NP_001101603.1  nuclear factor related to kappa-B-binding protein

    See identical proteins and their annotated locations for NP_001101603.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474007
    UniProtKB/TrEMBL
    A6JYG5
    Conserved Domains (1) summary
    pfam14465
    Location:392 → 476
    NFRKB_winged; NFRKB Winged Helix-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    38089574..38121506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242753.5 → XP_006242815.1  nuclear factor related to kappa-B-binding protein isoform X1

    See identical proteins and their annotated locations for XP_006242815.1

    UniProtKB/TrEMBL
    D4A421
    Related
    ENSRNOP00000011223.6, ENSRNOT00000011223.8
    Conserved Domains (1) summary
    pfam14465
    Location:404 → 488
    NFRKB_winged; NFRKB Winged Helix-like

  2. XM_063265380.1 → XP_063121450.1  nuclear factor related to kappa-B-binding protein isoform X4

  3. XM_006242756.5 → XP_006242818.1  nuclear factor related to kappa-B-binding protein isoform X3

    Conserved Domains (1) summary
    pfam14465
    Location:404 → 488
    NFRKB_winged; NFRKB Winged Helix-like

  4. XM_063265383.1 → XP_063121453.1  nuclear factor related to kappa-B-binding protein isoform X7

  5. XM_063265378.1 → XP_063121448.1  nuclear factor related to kappa-B-binding protein isoform X2

  6. XM_063265382.1 → XP_063121452.1  nuclear factor related to kappa-B-binding protein isoform X6

  7. XM_063265384.1 → XP_063121454.1  nuclear factor related to kappa-B-binding protein isoform X8

  8. XM_006242759.5 → XP_006242821.1  nuclear factor related to kappa-B-binding protein isoform X9

    UniProtKB/TrEMBL
    A0A0G2K0N5
    Conserved Domains (1) summary
    pfam14465
    Location:392 → 476
    NFRKB_winged; NFRKB Winged Helix-like

  9. XM_063265389.1 → XP_063121459.1  nuclear factor related to kappa-B-binding protein isoform X12

  10. XM_006242760.5 → XP_006242822.1  nuclear factor related to kappa-B-binding protein isoform X10

    See identical proteins and their annotated locations for XP_006242822.1

    UniProtKB/TrEMBL
    A6JYG5
    Conserved Domains (1) summary
    pfam14465
    Location:392 → 476
    NFRKB_winged; NFRKB Winged Helix-like

  11. XM_063265393.1 → XP_063121463.1  nuclear factor related to kappa-B-binding protein isoform X14

  12. XM_063265388.1 → XP_063121458.1  nuclear factor related to kappa-B-binding protein isoform X11

  13. XM_063265392.1 → XP_063121462.1  nuclear factor related to kappa-B-binding protein isoform X13

  14. XM_063265387.1 → XP_063121457.1  nuclear factor related to kappa-B-binding protein isoform X9

  15. XM_063265390.1 → XP_063121460.1  nuclear factor related to kappa-B-binding protein isoform X12

  16. XM_063265391.1 → XP_063121461.1  nuclear factor related to kappa-B-binding protein isoform X10

    UniProtKB/TrEMBL
    A6JYG5

  17. XM_063265377.1 → XP_063121447.1  nuclear factor related to kappa-B-binding protein isoform X1

    UniProtKB/TrEMBL
    D4A421

  18. XM_063265379.1 → XP_063121449.1  nuclear factor related to kappa-B-binding protein isoform X2

  19. XM_063265381.1 → XP_063121451.1  nuclear factor related to kappa-B-binding protein isoform X5

  20. XM_063265394.1 → XP_063121464.1  nuclear factor related to kappa-B-binding protein isoform X15

  21. XM_063265396.1 → XP_063121466.1  nuclear factor related to kappa-B-binding protein isoform X16

  22. XM_063265397.1 → XP_063121467.1  nuclear factor related to kappa-B-binding protein isoform X17

  23. XM_063265398.1 → XP_063121468.1  nuclear factor related to kappa-B-binding protein isoform X18

  24. XM_063265399.1 → XP_063121469.1  nuclear factor related to kappa-B-binding protein isoform X19

Nucleotide Protein Strain
Heading Accession and Version

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