U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tbcel tubulin folding cofactor E-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 315591, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
Tbcelprovided by RGD
Official Full Name
tubulin folding cofactor E-likeprovided by RGD
Primary source
RGD:1308880
See related
EnsemblRapid:ENSRNOG00000032364 AllianceGenome:RGD:1308880
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lrrc35; RGD1308880
Summary
Predicted to enable alpha-tubulin binding activity. Predicted to be involved in microtubule cytoskeleton organization; post-chaperonin tubulin folding pathway; and tubulin complex assembly. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Orthologous to human TBCEL (tubulin folding cofactor E like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 121.2), Thymus (RPKM 91.9) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Tbcel in Genome Data Viewer
Location:
8q22
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (51692660..51751560, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (42795648..42854552, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (46691488..46750816, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene tectorin alpha Neighboring gene uncharacterized LOC102549755 Neighboring gene uncharacterized LOC120094129

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in post-chaperonin tubulin folding pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tubulin complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tubulin-specific chaperone cofactor E-like protein
Names
leucine rich repeat containing 35
leucine-rich repeat-containing protein 35

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014089.2 → NP_001014111.1  tubulin-specific chaperone cofactor E-like protein

    See identical proteins and their annotated locations for NP_001014111.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q5PQJ7
    UniProtKB/TrEMBL
    A0A8I5ZV57
    Related
    ENSRNOP00000083279.1, ENSRNOT00000119305.2
    Conserved Domains (4) summary
    COG4886
    Location:47 → 225
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:78 → 101
    LRR_RI; leucine-rich repeat [structural motif]
    cd17045
    Location:337 → 422
    Ubl_TBCEL; ubiquitin-like (Ubl) domain found in tubulin-specific chaperone cofactor E-like protein (TBCEL) and similar proteins
    pfam14580
    Location:191 → 304
    LRR_9; Leucine-rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    51692660..51751560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081416.2 → XP_038937344.1  tubulin-specific chaperone cofactor E-like protein isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZV57, A0A8I6AFW9
    Related
    ENSRNOP00000091803.1, ENSRNOT00000115149.2
    Conserved Domains (4) summary
    COG4886
    Location:47 → 225
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:78 → 101
    LRR_RI; leucine-rich repeat [structural motif]
    cd17045
    Location:380 → 465
    Ubl_TBCEL; ubiquitin-like (Ubl) domain found in tubulin-specific chaperone cofactor E-like protein (TBCEL) and similar proteins
    pfam14580
    Location:191 → 304
    LRR_9; Leucine-rich repeat

  2. XM_006242859.5 → XP_006242921.1  tubulin-specific chaperone cofactor E-like protein isoform X3

    See identical proteins and their annotated locations for XP_006242921.1

    UniProtKB/TrEMBL
    A0A8I5ZV57, A0A8L2QRT5, A6J3T2
    Related
    ENSRNOP00000056698.2, ENSRNOT00000059951.4
    Conserved Domains (4) summary
    COG4886
    Location:65 → 243
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:93 → 277
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:96 → 119
    LRR_RI; leucine-rich repeat [structural motif]
    cl00155
    Location:363 → 437
    UBQ; Ubiquitin-like proteins

  3. XM_039081415.2 → XP_038937343.1  tubulin-specific chaperone cofactor E-like protein isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZV57
    Conserved Domains (4) summary
    COG4886
    Location:65 → 243
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:96 → 119
    LRR_RI; leucine-rich repeat [structural motif]
    cd17045
    Location:398 → 483
    Ubl_TBCEL; ubiquitin-like (Ubl) domain found in tubulin-specific chaperone cofactor E-like protein (TBCEL) and similar proteins
    pfam14580
    Location:209 → 322
    LRR_9; Leucine-rich repeat

  4. XM_039081418.2 → XP_038937346.1  tubulin-specific chaperone cofactor E-like protein isoform X5

    Conserved Domains (2) summary
    cd17045
    Location:230 → 315
    Ubl_TBCEL; ubiquitin-like (Ubl) domain found in tubulin-specific chaperone cofactor E-like protein (TBCEL) and similar proteins
    pfam14580
    Location:41 → 154
    LRR_9; Leucine-rich repeat

  5. XM_039081417.2 → XP_038937345.1  tubulin-specific chaperone cofactor E-like protein isoform X4

    Conserved Domains (3) summary
    sd00033
    Location:96 → 119
    LRR_RI; leucine-rich repeat [structural motif]
    pfam14580
    Location:209 → 322
    LRR_9; Leucine-rich repeat
    cd21340
    Location:90 → 316
    PPP1R42; protein phosphatase 1 regulatory subunit 42
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PQJ7.1 GenPept UniProtKB/Swiss-Prot:Q5PQJ7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools