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Thsd4 thrombospondin type 1 domain containing 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315728, updated on 6-Jun-2024

Summary

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Symbol
Thsd4provided by RGD
Full Name
thrombospondin type 1 domain containing 4provided by RGD
Primary source
RGD:1566296
See related
Ensembl:ENSRNOG00000053753 AllianceGenome:RGD:1566296
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1566296; AABR07070307.1
Summary
Predicted to act upstream of or within elastic fiber assembly. Predicted to be located in microfibril. Orthologous to human THSD4 (thrombospondin type 1 domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 72.9), Kidney (RPKM 45.0) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Thsd4 in Genome Data Viewer
Location:
8q24
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (69280397..69880144, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (60384636..60984419, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (64811940..65413498, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene myosin IXA Neighboring gene uncharacterized LOC102546766 Neighboring gene nuclear receptor subfamily 2, group E, member 3 Neighboring gene uncharacterized LOC134480061 Neighboring gene uncharacterized LOC120094180 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene leucine rich repeat containing 49 Neighboring gene uncharacterized LOC108351719 Neighboring gene peptidyl-prolyl cis-trans isomerase A-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ADAMTSL-6 is a novel extracellular matrix protein that binds to fibrillin-1 and promotes fibrillin-1 fibril formation. Tsutsui K, et al. J Biol Chem, 2010 Feb 12. PMID 19940141, Free PMC Article
  2. SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers. Zanivan S, et al. Mol Cell Proteomics, 2013 Dec. PMID 23979707, Free PMC Article
  3. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within elastic fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in microfibril assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in microfibril ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
thrombospondin type 1 domain containing 4; thrombospondin type-1 domain-containing protein 4
Names
thrombospondin, type I, domain containing 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429247.1 → NP_001416176.1  thrombospondin type 1 domain containing 4 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I6AN95

  2. NM_001429249.1 → NP_001416178.1  thrombospondin type 1 domain containing 4 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I6A1T6, A6J545

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    69280397..69880144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082429.2 → XP_038938357.1  thrombospondin type-1 domain-containing protein 4 isoform X1

    Related
    ENSRNOP00000094090.1
    Conserved Domains (4) summary
    PHA03247
    Location:34 → 213
    PHA03247; large tegument protein UL36; Provisional
    pfam05986
    Location:411 → 527
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:974 → 1004
    PLAC; PLAC (protease and lacunin) domain
    pfam19030
    Location:855 → 911
    TSP1_ADAMTS; Thrombospondin type 1 domain

  2. XM_039082430.2 → XP_038938358.1  thrombospondin type-1 domain-containing protein 4 isoform X2

    Related
    ENSRNOP00000085220.1
    Conserved Domains (3) summary
    pfam05986
    Location:52 → 168
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:615 → 645
    PLAC; PLAC (protease and lacunin) domain
    pfam19030
    Location:496 → 552
    TSP1_ADAMTS; Thrombospondin type 1 domain
Nucleotide Protein Strain
Heading Accession and Version

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