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Uaca uveal autoantigen with coiled-coil domains and ankyrin repeats [ Rattus norvegicus (Norway rat) ]

Gene ID: 315732, updated on 2-Nov-2024

Summary

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Official Symbol
Uacaprovided by RGD
Official Full Name
uveal autoantigen with coiled-coil domains and ankyrin repeatsprovided by RGD
Primary source
RGD:1560011
See related
EnsemblRapid:ENSRNOG00000012868 AllianceGenome:RGD:1560011
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560011
Summary
Predicted to enable transcription regulator inhibitor activity. Predicted to be involved in intrinsic apoptotic signaling pathway; negative regulation of inflammatory response; and negative regulation of intracellular signal transduction. Predicted to act upstream of or within several processes, including positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of protein import into nucleus; and response to UV. Predicted to be located in membrane; nucleus; and perinuclear region of cytoplasm. Predicted to be part of apoptosome. Predicted to be active in cytosol and nucleus. Orthologous to human UACA (uveal autoantigen with coiled-coil domains and ankyrin repeats). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 359.4), Heart (RPKM 182.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Uaca in Genome Data Viewer
Location:
8q24
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (70155059..70243416)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (61259415..61347789)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (65686586..65774940)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480063 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene hypothetical protein LOC691000 Neighboring gene uncharacterized LOC102551127

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of a novel, embryonal carcinoma cell-associated molecule, nucling, that is up-regulated during cardiac muscle differentiation. Sakai T, et al. J Biochem, 2003 Apr. PMID 12761289
  2. Nucling mediates apoptosis by inhibiting expression of galectin-3 through interference with nuclear factor kappaB signalling. Liu L, et al. Biochem J, 2004 May 15. PMID 14961764, Free PMC Article
  3. Nucling recruits Apaf-1/pro-caspase-9 complex for the induction of stress-induced apoptosis. Sakai T, et al. J Biol Chem, 2004 Sep 24. PMID 15271982
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transcription regulator inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
  
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of non-canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to UV ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of apoptosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
uveal autoantigen with coiled-coil domains and ankyrin repeats

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195564.1 → NP_001182493.1  uveal autoantigen with coiled-coil domains and ankyrin repeats

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I6GKP6, D3ZGS5
    Conserved Domains (4) summary
    pfam05483
    Location:534 → 1218
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    cd00204
    Location:99 → 222
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:107 → 199
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:136 → 166
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    70155059..70243416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243205.4 → XP_006243267.1  uveal autoantigen with coiled-coil domains and ankyrin repeats isoform X1

    See identical proteins and their annotated locations for XP_006243267.1

    UniProtKB/TrEMBL
    A0A8I6GKP6, A6J551
    Related
    ENSRNOP00000017233.7, ENSRNOT00000017233.9
    Conserved Domains (4) summary
    pfam05483
    Location:532 → 1216
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    cd00204
    Location:99 → 222
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:107 → 199
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:136 → 166
    ANK; ANK repeat [structural motif]

  2. XM_006243206.4 → XP_006243268.1  uveal autoantigen with coiled-coil domains and ankyrin repeats isoform X2

    UniProtKB/TrEMBL
    A0A0G2JT68, A0A8I6GKP6
    Related
    ENSRNOP00000110532.1, ENSRNOT00000140038.1
    Conserved Domains (4) summary
    pfam05483
    Location:517 → 1201
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    cd00204
    Location:84 → 207
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:92 → 184
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:121 → 151
    ANK; ANK repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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