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Kif23 kinesin family member 23 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315740, updated on 2-Nov-2024

Summary

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Official Symbol
Kif23provided by RGD
Official Full Name
kinesin family member 23provided by RGD
Primary source
RGD:1308596
See related
EnsemblRapid:ENSRNOG00000014080 AllianceGenome:RGD:1308596
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in several processes, including mitotic cytokinesis; mitotic spindle midzone assembly; and positive regulation of cytokinesis. Predicted to be located in several cellular components, including Flemming body; intercellular bridge; and microtubule cytoskeleton. Predicted to be part of centralspindlin complex and kinesin complex. Predicted to be active in cytoplasm; microtubule; and nucleus. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia type III. Orthologous to human KIF23 (kinesin family member 23). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 180.0), Spleen (RPKM 104.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kif23 in Genome Data Viewer
Location:
8q24
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (71293439..71321911, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (62397908..62425162, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (66866043..66893241, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552398 Neighboring gene ribosomal protein lateral stalk subunit P1 Neighboring gene progestin and adipoQ receptor family member 5 Neighboring gene glucuronic acid epimerase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Annexin 11 is required for midbody formation and completion of the terminal phase of cytokinesis. Tomas A, et al. J Cell Biol, 2004 Jun 21. PMID 15197175, Free PMC Article
  2. Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity. Mishima M, et al. Dev Cell, 2002 Jan. PMID 11782313
  3. Characterization of centrosomal proteins Cep55 and pericentrin in intercellular bridges of mouse testes. Chang YC, et al. J Cell Biochem, 2010 Apr 15. PMID 20186884
  4. An ECT2-centralspindlin complex regulates the localization and function of RhoA. Yüce O, et al. J Cell Biol, 2005 Aug 15. PMID 16103226, Free PMC Article
  5. Dissecting the role of Rho-mediated signaling in contractile ring formation. Kamijo K, et al. Mol Biol Cell, 2006 Jan. PMID 16236794, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle midzone assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle midzone assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Flemming body IEA
Inferred from Electronic Annotation
more info
  
located_in Flemming body ISO
Inferred from Sequence Orthology
more info
  
part_of centralspindlin complex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108155.1 → NP_001101625.1  kinesin-like protein KIF23

    See identical proteins and their annotated locations for NP_001101625.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473975
    UniProtKB/TrEMBL
    A0A8I6GJ20, A6J569, D4AAG4
    Related
    ENSRNOP00000033647.6, ENSRNOT00000037028.7
    Conserved Domains (4) summary
    cd01368
    Location:24 → 434
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam00225
    Location:31 → 436
    Kinesin; Kinesin motor domain
    pfam16540
    Location:796 → 895
    MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
    cl12013
    Location:483 → 621
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    71293439..71321911 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265498.1 → XP_063121568.1  kinesin-like protein KIF23 isoform X11

  2. XM_063265506.1 → XP_063121576.1  kinesin-like protein KIF23 isoform X20

  3. XM_039081487.2 → XP_038937415.1  kinesin-like protein KIF23 isoform X10

    UniProtKB/TrEMBL
    D4AAG4
    Conserved Domains (3) summary
    PRK03918
    Location:572 → 738
    PRK03918; DNA double-strand break repair ATPase Rad50
    cd01368
    Location:79 → 504
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam16540
    Location:863 → 892
    MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

  4. XM_063265493.1 → XP_063121563.1  kinesin-like protein KIF23 isoform X3

  5. XM_039081488.2 → XP_038937416.1  kinesin-like protein KIF23 isoform X12

    UniProtKB/TrEMBL
    D4AAG4
    Conserved Domains (3) summary
    PRK03918
    Location:557 → 723
    PRK03918; DNA double-strand break repair ATPase Rad50
    cd01368
    Location:79 → 489
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam16540
    Location:848 → 877
    MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

  6. XM_063265494.1 → XP_063121564.1  kinesin-like protein KIF23 isoform X5

  7. XM_039081483.2 → XP_038937411.1  kinesin-like protein KIF23 isoform X2

    UniProtKB/TrEMBL
    D4AAG4
    Conserved Domains (3) summary
    PRK03918
    Location:571 → 737
    PRK03918; DNA double-strand break repair ATPase Rad50
    cd01368
    Location:79 → 503
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam16540
    Location:865 → 967
    MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

  8. XM_039081489.2 → XP_038937417.1  kinesin-like protein KIF23 isoform X13

    UniProtKB/TrEMBL
    D4AAG4
    Conserved Domains (3) summary
    PRK03918
    Location:572 → 738
    PRK03918; DNA double-strand break repair ATPase Rad50
    cd01368
    Location:79 → 504
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam16540
    Location:762 → 864
    MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

  9. XM_039081482.2 → XP_038937410.1  kinesin-like protein KIF23 isoform X1

    UniProtKB/TrEMBL
    D4AAG4
    Conserved Domains (3) summary
    PRK03918
    Location:572 → 738
    PRK03918; DNA double-strand break repair ATPase Rad50
    cd01368
    Location:79 → 504
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam16540
    Location:866 → 968
    MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

  10. XM_063265502.1 → XP_063121572.1  kinesin-like protein KIF23 isoform X16

    UniProtKB/TrEMBL
    A0A0G2K7Y7

  11. XM_039081484.2 → XP_038937412.1  kinesin-like protein KIF23 isoform X4

    UniProtKB/TrEMBL
    D4AAG4
    Related
    ENSRNOP00000091527.2, ENSRNOT00000112104.2
    Conserved Domains (3) summary
    PRK03918
    Location:557 → 723
    PRK03918; DNA double-strand break repair ATPase Rad50
    cd01368
    Location:79 → 489
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam16540
    Location:851 → 953
    MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

  12. XM_063265496.1 → XP_063121566.1  kinesin-like protein KIF23 isoform X6

  13. XM_063265499.1 → XP_063121569.1  kinesin-like protein KIF23 isoform X14

  14. XM_063265505.1 → XP_063121575.1  kinesin-like protein KIF23 isoform X19

  15. XM_063265504.1 → XP_063121574.1  kinesin-like protein KIF23 isoform X18

    UniProtKB/TrEMBL
    A0A8I5ZWA3

  16. XM_039081486.2 → XP_038937414.1  kinesin-like protein KIF23 isoform X9

    UniProtKB/TrEMBL
    D4AAG4
    Conserved Domains (3) summary
    PRK03918
    Location:516 → 682
    PRK03918; DNA double-strand break repair ATPase Rad50
    cd01368
    Location:24 → 448
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam16540
    Location:810 → 912
    MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

  17. XM_063265503.1 → XP_063121573.1  kinesin-like protein KIF23 isoform X17

  18. XM_039081485.2 → XP_038937413.1  kinesin-like protein KIF23 isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZRP3, D4AAG4
    Related
    ENSRNOP00000074399.3, ENSRNOT00000091755.3
    Conserved Domains (3) summary
    PRK03918
    Location:517 → 683
    PRK03918; DNA double-strand break repair ATPase Rad50
    cd01368
    Location:24 → 449
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam16540
    Location:811 → 913
    MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

  19. XM_063265507.1 → XP_063121577.1  kinesin-like protein KIF23 isoform X21

  20. XM_063265500.1 → XP_063121570.1  kinesin-like protein KIF23 isoform X15

  21. XM_063265497.1 → XP_063121567.1  kinesin-like protein KIF23 isoform X7

    Related
    ENSRNOP00000107493.1, ENSRNOT00000134548.1
Nucleotide Protein Strain
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