U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Skor1 SKI family transcriptional corepressor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315748, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Skor1provided by RGD
Official Full Name
SKI family transcriptional corepressor 1provided by RGD
Primary source
RGD:1307687
See related
EnsemblRapid:ENSRNOG00000013959 AllianceGenome:RGD:1307687
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lbxcor1; RGD1307687
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SMAD binding activity. Predicted to be involved in negative regulation of BMP signaling pathway and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in dendrite and neuronal cell body. Predicted to be part of transcription regulator complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human SKOR1 (SKI family transcriptional corepressor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 5.9), Testes (RPKM 5.0) and 1 other tissue See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Skor1 in Genome Data Viewer
Location:
8q24
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (72494554..72505127, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (63599153..63609727, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (68029930..68040504, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A , pseudogene 16 Neighboring gene U6 spliceosomal RNA Neighboring gene mitogen activated protein kinase kinase 5 Neighboring gene uncharacterized LOC134480190 Neighboring gene uncharacterized LOC102547003 Neighboring gene similar to human chromosome 15 open reading frame 61

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling. Arndt S, et al. Mol Cell Neurosci, 2007 Apr. PMID 17292623
  2. Corl1, a novel neuronal lineage-specific transcriptional corepressor for the homeodomain transcription factor Lbx1. Mizuhara E, et al. J Biol Chem, 2005 Feb 4. PMID 15528197
  3. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
SKI family transcriptional corepressor 1
Names
ladybird homeobox 1 homolog corepressor 1
ladybird homeobox corepressor 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001376952.1 → NP_001363881.1  SKI family transcriptional corepressor 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    P84551
    Related
    ENSRNOP00000018756.5, ENSRNOT00000018756.6
    Conserved Domains (3) summary
    smart01046
    Location:180 → 272
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    pfam02437
    Location:75 → 168
    Ski_Sno; SKI/SNO/DAC family
    pfam15236
    Location:850 → 934
    CCDC66; Coiled-coil domain-containing protein 66

  2. NM_001376953.1 → NP_001363882.1  SKI family transcriptional corepressor 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000008
    Conserved Domains (3) summary
    smart01046
    Location:141 → 233
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    pfam02437
    Location:36 → 129
    Ski_Sno; SKI/SNO/DAC family
    pfam15236
    Location:811 → 895
    CCDC66; Coiled-coil domain-containing protein 66

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    72494554..72505127 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P84551.1 GenPept UniProtKB/Swiss-Prot:P84551

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools