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Parp16 poly (ADP-ribose) polymerase family, member 16 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315760, updated on 2-Nov-2024

Summary

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Official Symbol
Parp16provided by RGD
Official Full Name
poly (ADP-ribose) polymerase family, member 16provided by RGD
Primary source
RGD:1306243
See related
AllianceGenome:RGD:1306243
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ARTD15; LRRGT00109; RGD1306243
Summary
Predicted to enable NAD+-protein ADP-ribosyltransferase activity; kinase binding activity; and protein serine/threonine kinase activator activity. Predicted to be involved in IRE1-mediated unfolded protein response; negative regulation of cytoplasmic translation; and protein auto-ADP-ribosylation. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum tubular network and nuclear envelope. Orthologous to human PARP16 (poly(ADP-ribose) polymerase family member 16). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 78.9), Adrenal (RPKM 72.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Parp16 in Genome Data Viewer
Location:
8q24
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (74626399..74644610)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (65731152..65749438)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (70712393..70731212)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene U5 spliceosomal RNA Neighboring gene U5 spliceosomal RNA Neighboring gene uncharacterized LOC134480196 Neighboring gene cartilage intermediate layer protein Neighboring gene caseinolytic mitochondrial matrix peptidase chaperone subunit X

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Smyd3-PARP16 axis accelerates unfolded protein response and vascular aging. Yang D, et al. Aging (Albany NY), 2020 Nov 3. PMID 33144524, Free PMC Article
  2. PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-ß1. Di Paola S, et al. PLoS One, 2012. PMID 22701565, Free PMC Article
  3. PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response. Jwa M, et al. Nat Cell Biol, 2012 Nov. PMID 23103912, Free PMC Article
  4. Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation. Barkauskaite E, et al. Mol Cell, 2015 Jun 18. PMID 26091342
  5. Family-wide analysis of poly(ADP-ribose) polymerase activity. Vyas S, et al. Nat Commun, 2014 Jul 21. PMID 25043379, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Smyd3-PARP16 axis accelerates unfolded protein response and vascular aging.
    Title: Smyd3-PARP16 axis accelerates unfolded protein response and vascular aging.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAD+-protein ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables NAD+-protein ADP-ribosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+-protein poly-ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+-protein poly-ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables NAD+-protein-aspartate ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+-protein-aspartate ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables NAD+-protein-aspartate ADP-ribosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables NAD+-protein-glutamate ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+-protein-glutamate ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables NAD+-protein-glutamate ADP-ribosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables NAD+-protein-lysine ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+-protein-lysine ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables NAD+-protein-lysine ADP-ribosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response IEA
Inferred from Electronic Annotation
more info
  
involved_in IRE1-mediated unfolded protein response ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum unfolded protein response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cytoplasmic translation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein auto-ADP-ribosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein auto-ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein auto-ADP-ribosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum tubular network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum tubular network IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum tubular network ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein mono-ADP-ribosyltransferase PARP16
Names
ADP-ribosyltransferase diphtheria toxin-like 15
PARP-16
mono [ADP-ribose] polymerase PARP16
poly [ADP-ribose] polymerase 16
NP_001014115.1
XP_038937432.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014093.1 → NP_001014115.1  protein mono-ADP-ribosyltransferase PARP16

    See identical proteins and their annotated locations for NP_001014115.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085908
    UniProtKB/Swiss-Prot
    Q5U2Q4
    UniProtKB/TrEMBL
    A6J5E5
    Conserved Domains (2) summary
    pfam00644
    Location:102 → 273
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam18084
    Location:15 → 90
    ARTD15_N; ARTD15 N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    74626399..74644610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081504.2 → XP_038937432.1  protein mono-ADP-ribosyltransferase PARP16 isoform X1

    UniProtKB/Swiss-Prot
    Q5U2Q4
    UniProtKB/TrEMBL
    A6J5E5
    Conserved Domains (2) summary
    pfam00644
    Location:102 → 273
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam18084
    Location:15 → 90
    ARTD15_N; ARTD15 N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U2Q4.1 GenPept UniProtKB/Swiss-Prot:Q5U2Q4

Gene LinkOut

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