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Herc1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315771, updated on 10-Jul-2024

Summary

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Official Symbol
Herc1provided by RGD
Official Full Name
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1provided by RGD
Primary source
RGD:1306366
See related
EnsemblRapid:ENSRNOG00000051671 AllianceGenome:RGD:1306366
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. Predicted to act upstream of or within negative regulation of autophagy; neuromuscular process controlling balance; and neuron differentiation. Orthologous to human HERC1 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 351.7), Spleen (RPKM 349.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Herc1 in Genome Data Viewer
Location:
8q24
Exon count:
79
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (75796347..75965347)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (66857169..67070318)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (72029550..72198363)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene death-associated protein kinase 2 Neighboring gene uncharacterized LOC108351731 Neighboring gene uncharacterized LOC134480197 Neighboring gene F-box and leucine-rich repeat protein 22 Neighboring gene ubiquitin specific peptidase 3 Neighboring gene uncharacterized LOC120094375

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Progressive Purkinje cell degeneration in tambaleante mutant mice is a consequence of a missense mutation in HERC1 E3 ubiquitin ligase. Mashimo T, et al. PLoS Genet, 2009 Dec. PMID 20041218, Free PMC Article
  2. The E3 ubiquitin ligase HERC1 controls the ERK signaling pathway targeting C-RAF for degradation. Schneider T, et al. Oncotarget, 2018 Jul 31. PMID 30140388, Free PMC Article
  3. Target neuron controls the integrity of afferent axon phenotype: a study on the Purkinje cell-climbing fiber system in cerebellar mutant mice. Rossi F, et al. J Neurosci, 1995 Mar. PMID 7891151, Free PMC Article
  4. Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins. Besche HC, et al. Biochemistry, 2009 Mar 24. PMID 19182904, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of autophagy ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within brain development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cerebellar Purkinje cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within corpus callosum development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuromuscular process controlling balance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron projection development ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
probable E3 ubiquitin-protein ligase HERC1
Names
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
NP_001407845.1
XP_017451567.1
XP_038938405.1
XP_063121593.1
XP_063121594.1
XP_063121595.1
XP_063121596.1
XP_063121597.1
XP_063121598.1
XP_063121599.1
XP_063121600.1
XP_063121601.1
XP_063121602.1
XP_063121603.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420916.1 → NP_001407845.1  probable E3 ubiquitin-protein ligase HERC1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A0G2JTT6, A0A8I5ZV70

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    75796347..75965347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265523.1 → XP_063121593.1  probable E3 ubiquitin-protein ligase HERC1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZV70

  2. XM_063265529.1 → XP_063121599.1  probable E3 ubiquitin-protein ligase HERC1 isoform X7

    UniProtKB/TrEMBL
    A0A8I5ZV70

  3. XM_063265525.1 → XP_063121595.1  probable E3 ubiquitin-protein ligase HERC1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZV70

  4. XM_063265531.1 → XP_063121601.1  probable E3 ubiquitin-protein ligase HERC1 isoform X10

    UniProtKB/TrEMBL
    A0A8I5ZV70

  5. XM_063265527.1 → XP_063121597.1  probable E3 ubiquitin-protein ligase HERC1 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZV70

  6. XM_063265524.1 → XP_063121594.1  probable E3 ubiquitin-protein ligase HERC1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZV70

  7. XM_063265526.1 → XP_063121596.1  probable E3 ubiquitin-protein ligase HERC1 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZV70

  8. XM_063265528.1 → XP_063121598.1  probable E3 ubiquitin-protein ligase HERC1 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZV70

  9. XM_017596078.3 → XP_017451567.1  probable E3 ubiquitin-protein ligase HERC1 isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZV70
    Related
    ENSRNOP00000068838.3, ENSRNOT00000089336.3
    Conserved Domains (9) summary
    smart00119
    Location:4519 → 4852
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    COG2319
    Location:3409 → 3793
    WD40; WD40 repeat [General function prediction only]
    cd00078
    Location:4488 → 4856
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:2751 → 2794
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    pfam00415
    Location:4115 → 4164
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:4308 → 4337
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat
    sd00039
    Location:3447 → 3490
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:2030 → 2187
    SPRY_HERC1; SPRY domain in HERC1
    cl02567
    Location:3439 → 3790
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  10. XM_063265532.1 → XP_063121602.1  probable E3 ubiquitin-protein ligase HERC1 isoform X11

    UniProtKB/TrEMBL
    A0A8I5ZV70

  11. XM_063265530.1 → XP_063121600.1  probable E3 ubiquitin-protein ligase HERC1 isoform X9

    UniProtKB/TrEMBL
    A0A8I5ZV70

  12. XM_063265533.1 → XP_063121603.1  probable E3 ubiquitin-protein ligase HERC1 isoform X13

  13. XM_039082477.1 → XP_038938405.1  probable E3 ubiquitin-protein ligase HERC1 isoform X12

    UniProtKB/TrEMBL
    A6J5I1
    Conserved Domains (6) summary
    COG5184
    Location:2683 → 3031
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:3158 → 3526
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:1421 → 1464
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:2117 → 2160
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:700 → 857
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:2109 → 2460
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein Strain
Heading Accession and Version

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