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Klhl31 kelch-like family member 31 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315833, updated on 2-Nov-2024

Summary

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Official Symbol
Klhl31provided by RGD
Official Full Name
kelch-like family member 31provided by RGD
Primary source
RGD:1560540
See related
EnsemblRapid:ENSRNOG00000006224 AllianceGenome:RGD:1560540
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560540
Summary
Predicted to be involved in negative regulation of JNK cascade and negative regulation of protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Orthologous to human KLHL31 (kelch like family member 31). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 1246.2) and Heart (RPKM 604.6) See more
Orthologs
human mouse all
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Genomic context

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See Klhl31 in Genome Data Viewer
Location:
8q24
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (87395878..87419236)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (78515514..78538873)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (84945444..84968811)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094211 Neighboring gene uncharacterized LOC108351748 Neighboring gene uncharacterized LOC134480075 Neighboring gene ribosomal protein L27a, pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel human BTB-kelch protein KLHL31, strongly expressed in muscle and heart, inhibits transcriptional activities of TRE and SRE. Yu W, et al. Mol Cells, 2008 Nov 30. PMID 18719355
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in negative regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kelch-like protein 31
Names
kelch-like 31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108170.2 → NP_001101640.1  kelch-like protein 31

    See identical proteins and their annotated locations for NP_001101640.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6I1G5, D3ZLT6
    Related
    ENSRNOP00000008243.2, ENSRNOT00000008244.5
    Conserved Domains (4) summary
    PHA03098
    Location:73 → 601
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:356 → 405
    Kelch; KELCH repeat [structural motif]
    cd18260
    Location:55 → 174
    BTB_POZ_KLHL31_KBTBD1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31)
    cl28903
    Location:167 → 264
    BACK; BACK (BTB and C-terminal Kelch) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    87395878..87419236
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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