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Tbc1d2b TBC1 domain family, member 2B [ Rattus norvegicus (Norway rat) ]

Gene ID: 315880, updated on 2-Nov-2024

Summary

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Official Symbol
Tbc1d2bprovided by RGD
Official Full Name
TBC1 domain family, member 2Bprovided by RGD
Primary source
RGD:1307436
See related
EnsemblRapid:ENSRNOG00000014543 AllianceGenome:RGD:1307436
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307436
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in endocytosis. Predicted to be located in cytosol and early endosome. Orthologous to human TBC1D2B (TBC1 domain family member 2B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 223.9), Spleen (RPKM 124.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tbc1d2b in Genome Data Viewer
Location:
8q31
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (99626019..99694669, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (90746220..90814867, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (97577551..97647072, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene transfer RNA lysine (anticodon CUU) 18 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif, 7 Neighboring gene translocase of outer mitochondrial membrane 7, pseudogene 1 Neighboring gene uncharacterized LOC134479983

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Functional dissection of Rab GTPases involved in primary cilium formation. Yoshimura S, et al. J Cell Biol, 2007 Jul 30. PMID 17646400, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
TBC1 domain family member 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001413794.1 → NP_001400723.1  TBC1 domain family member 2B

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I6ALB6
    Related
    ENSRNOP00000093906.1, ENSRNOT00000119718.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    99626019..99694669 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265567.1 → XP_063121637.1  TBC1 domain family member 2B isoform X3

  2. XM_039081539.2 → XP_038937467.1  TBC1 domain family member 2B isoform X2

    UniProtKB/TrEMBL
    A6I221, D3ZAF7
    Conserved Domains (2) summary
    COG1196
    Location:109 → 338
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00566
    Location:435 → 646
    RabGAP-TBC; Rab-GTPase-TBC domain

  3. XM_039081538.2 → XP_038937466.1  TBC1 domain family member 2B isoform X1

    UniProtKB/TrEMBL
    A6I221, D3ZAF7
    Conserved Domains (3) summary
    COG1196
    Location:339 → 568
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01265
    Location:36 → 144
    PH_TBC1D2A; TBC1 domain family member 2A pleckstrin homology (PH) domain
    cl02495
    Location:659 → 799
    RabGAP-TBC; Rab-GTPase-TBC domain
Nucleotide Protein Strain
Heading Accession and Version

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