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Plscr2 phospholipid scramblase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315883, updated on 2-Nov-2024

Summary

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Official Symbol
Plscr2provided by RGD
Official Full Name
phospholipid scramblase 2provided by RGD
Primary source
RGD:1359107
See related
EnsemblRapid:ENSRNOG00000064984 AllianceGenome:RGD:1359107
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phospholipid scramblase activity. Predicted to be involved in cellular response to lipopolysaccharide and plasma membrane phospholipid scrambling. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 768.8), Lung (RPKM 219.4) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Plscr2 in Genome Data Viewer
Location:
8q31
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (101689202..101725726)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (92809422..92845947)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (99650351..99725514)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094226 Neighboring gene uncharacterized LOC102550510 Neighboring gene phospholipid scramblase 1 Neighboring gene phospholipid scramblase 1 like 1 Neighboring gene uncharacterized LOC134480085 Neighboring gene phospholipid scramblase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Stimulation of phosphatidylserine biosynthesis and facilitation of UV-induced apoptosis in Chinese hamster ovary cells overexpressing phospholipid scramblase 1. Yu A, et al. J Biol Chem, 2003 Mar 14. PMID 12509439
  2. Expression of the phospholipid scramblase (PLSCR) gene family during the acute phase response. Lu B, et al. Biochim Biophys Acta, 2007 Sep. PMID 17590392
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phospholipid scramblase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
  
involved_in plasma membrane phospholipid scrambling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phospholipid scramblase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014094.2 → NP_001014116.1  phospholipid scramblase 2 isoform 1

    See identical proteins and their annotated locations for NP_001014116.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I6AEL2, Q6AYD7
    Related
    ENSRNOP00000091509.2, ENSRNOT00000116380.2
    Conserved Domains (2) summary
    pfam03803
    Location:88 → 308
    Scramblase; Scramblase
    pfam11029
    Location:2 → 99
    DAZAP2; DAZ associated protein 2 (DAZAP2)

  2. NM_001423657.1 → NP_001410586.1  phospholipid scramblase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    Related
    ENSRNOP00000086482.2, ENSRNOT00000108295.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    101689202..101725726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081540.2 → XP_038937468.1  phospholipid scramblase 2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JYB5, A0A8I6AEL2
    Conserved Domains (1) summary
    pfam03803
    Location:86 → 306
    Scramblase

  2. XM_063265573.1 → XP_063121643.1  phospholipid scramblase 2 isoform X3

  3. XM_063265572.1 → XP_063121642.1  phospholipid scramblase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A3V8, A6I240

  4. XM_063265571.1 → XP_063121641.1  phospholipid scramblase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A3V8, A6I240
Nucleotide Protein Strain
Heading Accession and Version

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