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Nrk Nik related kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 315907, updated on 10-Jul-2024

Summary

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Official Symbol
Nrkprovided by RGD
Official Full Name
Nik related kinaseprovided by RGD
Primary source
RGD:1566163
See related
EnsemblRapid:ENSRNOG00000008880 AllianceGenome:RGD:1566163
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1566163
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including MAPK cascade; actin cytoskeleton reorganization; and regulation of MAPK cascade. Predicted to act upstream of or within several processes, including parturition; positive regulation of JNK cascade; and regulation of spongiotrophoblast cell proliferation. Predicted to be active in cytoplasm. Orthologous to human NRK (Nik related kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 34.9), Muscle (RPKM 34.5) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nrk in Genome Data Viewer
Location:
Xq32
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (107159154..107256417)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (102365765..102462957)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (109940439..110036361) , (110065199..110089124)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor accessory protein-like 2 Neighboring gene zinc finger CCCH domain-containing protein 14-like Neighboring gene large ribosomal subunit protein eL18-like Neighboring gene UBX domain protein 2A, pseudogene 1 Neighboring gene ATP binding cassette subfamily E member 1, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. NESK, a member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and is expressed during the late stages of embryogenesis. Nakano K, et al. J Biol Chem, 2000 Jul 7. PMID 10801798
  2. Nrk, an X-linked protein kinase in the germinal center kinase family, is required for placental development and fetoplacental induction of labor. Denda K, et al. J Biol Chem, 2011 Aug 19. PMID 21715335, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within parturition ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of spongiotrophoblast cell proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nik-related protein kinase
NP_001178726.1
NP_001398520.1
XP_063136078.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191797.1 → NP_001178726.1  nik-related protein kinase isoform 2

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    F1LZB6
    Related
    ENSRNOP00000053882.3, ENSRNOT00000057049.5
    Conserved Domains (4) summary
    smart00220
    Location:25 → 296
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    PRK10927
    Location:458 → 638
    PRK10927; essential cell division protein FtsN; Provisional
    cl02434
    Location:1141 → 1421
    CNH; CNH domain
    cl21453
    Location:14 → 296
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001411591.1 → NP_001398520.1  nik-related protein kinase isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    Related
    ENSRNOP00000099115.1, ENSRNOT00000165919.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    107159154..107256417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063280008.1 → XP_063136078.1  nik-related protein kinase isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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