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Pls1 plastin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315926, updated on 10-Oct-2024

Summary

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Official Symbol
Pls1provided by RGD
Official Full Name
plastin 1provided by RGD
Primary source
RGD:1307142
See related
EnsemblRapid:ENSRNOG00000009945 AllianceGenome:RGD:1307142
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in several processes, including actin filament organization; inner ear receptor cell stereocilium organization; and intestinal D-glucose absorption. Predicted to act upstream of or within terminal web assembly. Predicted to be located in brush border; stereocilium; and terminal web. Predicted to be active in actin filament; actin filament bundle; and cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 76. Orthologous to human PLS1 (plastin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 189.2), Liver (RPKM 95.9) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pls1 in Genome Data Viewer
Location:
8q31
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (105196312..105306252, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (96316703..96426592, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (103557361..103659625, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene procollagen C-endopeptidase enhancer 2 Neighboring gene inosine triphosphatase, pseudogene 1 Neighboring gene transient receptor potential cation channel, subfamily C, member 1 Neighboring gene uncharacterized LOC120094233 Neighboring gene uncharacterized LOC120094232 Neighboring gene ATR serine/threonine kinase Neighboring gene BCL2 interacting protein 3, pseudogene 2 Neighboring gene uncharacterized LOC120094234 Neighboring gene 5'-3' exoribonuclease 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC189074

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament network formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in auditory receptor cell stereocilium organization ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in intestinal D-glucose absorption ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in microvillus assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microvillus length ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within terminal web assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in terminal web assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in vestibular receptor cell stereocilium organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in actin filament bundle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in brush border ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in stereocilium ISO
Inferred from Sequence Orthology
more info
  
located_in terminal web ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
plastin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108178.3 → NP_001101648.3  plastin-1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  2. NM_001433806.1 → NP_001420735.1  plastin-1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  3. NM_001433807.1 → NP_001420736.1  plastin-1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  4. NM_001433808.1 → NP_001420737.1  plastin-1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    105196312..105306252 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081542.2 → XP_038937470.1  plastin-1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2QC04
    Conserved Domains (2) summary
    COG5069
    Location:13 → 622
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cl00030
    Location:100 → 244
    CH_SF; calponin homology (CH) domain superfamily

  2. XM_006243574.4 → XP_006243636.1  plastin-1 isoform X1

    See identical proteins and their annotated locations for XP_006243636.1

    UniProtKB/TrEMBL
    A0A0G2QC04
    Related
    ENSRNOP00000106829.1, ENSRNOT00000147926.1
    Conserved Domains (2) summary
    COG5069
    Location:13 → 622
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cl00030
    Location:100 → 244
    CH_SF; calponin homology (CH) domain superfamily

  3. XM_063265574.1 → XP_063121644.1  plastin-1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2QC04
Nucleotide Protein Strain
Heading Accession and Version

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